Evidence map›Paper›PMID 40770832›Full record

ArticleGut microbes2025

Aging: a possible road toward gut microbiota pathoadaptation.

Rita Melo-Miranda, Ana Pinto, Hugo C Barreto, Catarina S H Jesus, Isabel Gordo, Iola F Duarte, Ana Sousa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rita Melo-MirandaInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.ORCID 0000-0001-7845-5767
Ana PintoInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Hugo C BarretoUniversité Paris Cité, CNRS, Inserm, Institut Cochin, Paris, France.ORCID 0000-0002-6980-1047
Catarina S H JesusDepartment of Chemistry, CICECO - Aveiro Institute of Materials & LAQV-REQUIMTE, University of Aveiro, Aveiro, Portugal.
Isabel GordoGulbenkian Institute for Molecular Medicine (GIMM), Lisbon, Portugal.ORCID 0000-0003-1622-5143
Iola F DuarteDepartment of Chemistry, CICECO - Aveiro Institute of Materials & LAQV-REQUIMTE, University of Aveiro, Aveiro, Portugal.ORCID 0000-0003-4289-9256
Ana SousaInstitute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.ORCID 0000-0001-8541-5720

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laboratory-raised mice live approximately seven times longer and healthier lives compared to their wild counterparts, due to a standardized healthy diet and limited exposure to environmental stressors. Aging is associated with increased inflammation and microbial dysbiosis. Collectively, these influence microbiota evolution and may contribute to the enrichment in pathobiont frequency observed in old age. Alternatively, this increase could stem from a decline in colonization resistance, creating favorable conditions for pathobiont invasion. Here, we sought to test whether aging in healthy, controlled conditions, could prevent the selection of age-associated pathobionts. We have followed the adaptive evolution of a commensal strain of

Indexed as

AgingEscherichia coliGastrointestinal MicrobiomeAdaptation, PhysiologicalAkkermansiaAnimalsBiofilmsDysbiosisMaleMiceMice, Inbred C57BLMutationAgingEscherichia coliexperimental evolutionmicrobiotapathoadaptation

Identifiers

PMID40770832
PMCPMC12332998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.