ArticleBMC public health2025
The comparative burden of brain and central nervous system cancers from 1990 to 2021 between China, the United States, the United Kingdom, and Japan.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Gender disparities in the global burden of nasopharyngeal carcinoma: persistence and evolution of male predominance.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
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4 authors.
Funding
Abstract
backgroundBrain and central nervous system (CNS) cancers impose a substantial and growing disease burden in China, marked by elevated mortality and disability rates. Understanding disparities in cancer control strategies between China and developed countries (the US, the UK, and Japan) may inform evidence-based policy improvements.
methodsUsing Global Burden of Disease (GBD) 2021 data, we analyzed incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for brain and CNS cancers (1990-2021). Trends were assessed via estimated annual percentage change (EAPC), while frontier analysis evaluated disease burden reduction capacity relative to socioeconomic development. Health inequalities were measured using the Slope Inequality Index (SII) and Concentration Index. Future trends were projected via ARIMA models.
resultsIn 2021, China reported 105,541 new cases and 68,911 deaths. While China had lower age-standardized incidence (ASIR) and prevalence (ASPR) rates than comparison nations, its DALYs rate was higher. From 1990 to 2021, ASIR and ASPR increased universally, whereas age-standardized mortality (ASMR) and DALYs (ASDR) declined in China, the US, and the UK but rose in Japan. High-SDI regions exhibited greater burden mitigation capacity, with widening cross-country inequalities. Projections indicate rising ASIR in all nations by 2036.
conclusionsDespite declining mortality, China's brain and CNS cancer burden remains disproportionately high. Policymakers should integrate effective strategies from developed nations while tailoring interventions to China's unique epidemiological and healthcare context.
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