Evidence map›Paper›PMID 40770605›Full record

ArticleThe journal of headache and pain2025

Compromised PGF2α signaling in the paraventricular hypothalamic nucleus contributes to the central sensitization of the nitroglycerin-induced chronic migraine in male mice.

Xianrong Hu, Lunquan Wu, Li Wang, Congxue Peng, Yunyun Tian, Qian Zhu, Hongwei Zhu, Liang Nie, Li Yin, Yuehui Zhang and 1 more

Abstract read
In one paragraph

Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xianrong Hu *Department of Anesthesiology, Panzhihua Central Hospital, Panzhihua, 617000, China.
Lunquan Wu *Department of Anesthesiology, Fushun People's Hospital, Zigong, 643200, China.
Li WangDepartment of Anesthesiology, Panzhihua Central Hospital, Panzhihua, 617000, China.
Congxue PengDepartment of Anesthesiology, Panzhihua Central Hospital, Panzhihua, 617000, China.
Yunyun TianClinical Research Center, Panzhihua Central Hospital, Panzhihua, 617000, China.
Qian ZhuClinical Research Center, Panzhihua Central Hospital, Panzhihua, 617000, China.
Hongwei ZhuDepartment of Dermatology, Panzhihua Central Hospital, Panzhihua, 617000, China.
Liang NieDepartment of Anesthesiology, Fushun People's Hospital, Zigong, 643200, China.
Li YinClinical Research Center, Panzhihua Central Hospital, Panzhihua, 617000, China. 425281415@qq.com.
Yuehui ZhangDepartment of Neurology, Panzhihua Central Hospital, Panzhihua, 617000, China. zyh18096306699@163.com.
Jiang BianDepartment of Anesthesiology, Panzhihua Central Hospital, Panzhihua, 617000, China. 1105593984@qq.com.

Funding

Health Commission of Sichuan Province Medical Science and Technology Program 24QNMP019Innovative Program for the Integration of Meteorological Medicine and Engineering and Application Transformation in Panzhihua 2023ZD-C-1
6 · The paper itself

Abstract

Impaired descending inhibitory controls are now understood to exacerbate central sensitization of chronic migraine, yet the underlying neural and molecular mechanisms remain largely elusive. Herein, a paraventricular hypothalamic nucleus (PVN)

Indexed as

Central Nervous System SensitizationDinoprostMigraine DisordersParaventricular Hypothalamic NucleusSignal TransductionAnimalsChronic DiseaseDisease Models, AnimalHyperalgesiaMaleMiceMice, Inbred C57BLNeuronsNitroglycerinOxytocinReceptors, ProstaglandinDinoprostNitroglycerinOxytocinprostaglandin F2alpha receptorReceptors, ProstaglandinCentral sensitizationChronic migraineDescending pain modulationPGF2α signaling

Identifiers

PMID40770605
PMCPMC12326868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.