Evidence map›Paper›PMID 40770597›Full record

ArticleMolecular imaging and biology2025

PET Study of S1PR1 Expression in Rodent Model of Myocardial Infarction.

Hong Chen, Lin Qiu, Hao Jiang, Wenjuan Zhou, Anil Kumar Soda, Attila Kovacs, Carla J Weinheimer, Robert J Gropler, Zhude Tu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong ChenDepartment of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO, 63100, USA.
Lin QiuDepartment of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO, 63100, USA.
Hao JiangDepartment of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO, 63100, USA.
Wenjuan ZhouDepartment of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO, 63100, USA.
Anil Kumar SodaDepartment of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO, 63100, USA.
Attila KovacsDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, 63100, USA.
Carla J WeinheimerDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, 63100, USA.
Robert J GroplerDepartment of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO, 63100, USA.
Zhude TuDepartment of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO, 63100, USA. zhudetu@wustl.edu.ORCID 0000-0003-0325-835X

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
Acquisition of high-resolution PET/CT preclinical imaging instrument at MIRS10OD030403 · OD · WASHINGTON UNIVERSITY · PI SHOGHI, KOORESH ISAAC · 2021 to 2021
$929k
DEVELOPMENT OF VESICULAR ACETYLCHOLINE TRANSPORTER IMAGING AGENTS FOR PETR21NS061025 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2009 to 2010
$628k
HIGH-RESOLUTON ULTRASOUND SYSTEM FOR PHENOTYPIC EVALUATION OF THE CARDIOVASCULAR SYSTEM IN MICES10OD028597 · OD · WASHINGTON UNIVERSITY · PI KOVACS, ATTILA · 2020 to 2020
$378k
NIBIB NIH HHS EB025815NIBIB NIH HHS P41 EB025815NIH HHS S10 OD028597NIH HHS S10 OD030403NINDS NIH HHS NS061025NINDS NIH HHS NS075527NINDS NIH HHS NS103988NINDS NIH HHS NS134586NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS134586NINDS NIH HHS R21 NS061025
6 · The paper itself

Abstract

purposeAcute myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator influencing numerous physiological processes. S1PR1 is the predominant isoform of the S1P receptor in cardiomyocytes and vascular endothelial cells. S1PR1 plays a critical role in preventing adverse cardiac remodeling. The importance of S1PR1 in cardiac physiology has led to the development of novel treatments for MI, including S1PR1 gene delivery strategies aimed at preventing heart failure. Monitoring the dynamic changes of S1PR1 post-MI is clinically significant for assessing cardiac remodeling. This study validated the ability of specific S1PR1 PET radiotracer [ PROCEDURES: We characterized the S1PR1 radiotracer [

resultsThe uptake of [

conclusionsThis study demonstrated the downregulation of S1PR1 expression following MI and validated the use of [

Indexed as

Myocardial InfarctionPositron-Emission TomographySphingosine-1-Phosphate ReceptorsAnimalsDisease Models, AnimalFluorodeoxyglucose F18MaleMiceMice, Inbred C57BLMyocardiumFluorodeoxyglucose F18S1pr1 protein, mouseSphingosine-1-Phosphate ReceptorsAutoradiographyMyocardial infarctionPET imagingRemodelingS1PR1

Identifiers

PMID40770597
PMCPMC13108223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.