ArticleAesthetic plastic surgery2026
High-Dose Hyaluronidase for Late-Onset Vascular Complications Following Hyaluronic Acid Filler.
Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-onset vascular complications (VCs) following hyaluronic acid (HA) filler injections are rare but can result in significant morbidity if not promptly recognized and managed. We report a case of a 41-year-old woman who developed delayed VCs 28 h post-injection, unresponsive to low-dose hyaluronidase. Escalation to high-dose hyaluronidase (6000 IU), combined with platelet-rich fibrin (PRF) and hyperbaric oxygen therapy (HBOT), led to full recovery without adverse effects. This case highlights the clinical challenge of delayed VCs and the potential efficacy of aggressive, multimodal management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.