Evidence map›Paper›PMID 40770481›Full record

SynthesisSports medicine - open2025

Comparative Analysis of Multidisciplinary Complementary Intervention Versus Routine Physiotherapy Rehabilitation to Reduce Kinesiophobia in Patients with Knee Osteoarthritis Undergoing Total Knee Replacement: A Systematic Review and Meta-Analysis.

Hung Tzu-Han, Liu Mei-Chun, Kuo Ya-Wen, Lee Jiann-Der

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sports medicine - open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hung Tzu-HanDivision of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Liu Mei-Chun *Department of Nursing, College of Nursing, Chang Gung University of Science and Technology (CGUST), No. 2, Sec. W., Jiapu Rd, Puzi, Chiayi, 61363, Taiwan.
Kuo Ya-Wen *Department of Nursing, College of Nursing, Chang Gung University of Science and Technology (CGUST), No. 2, Sec. W., Jiapu Rd, Puzi, Chiayi, 61363, Taiwan. ywkuo@mail.cgust.edu.tw.
Lee Jiann-Der *Department of Neurology, Chang Gung Memorial Hospital, No. 6, West Sec., Jiapu Road, Puzi, Chiayi, 61363, Taiwan. jdlee540908@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKnee osteoarthritis is a highly prevalent disease that affects 24-31.8% of patients who undergo total knee replacement (TKR); it impedes their rehabilitation and increases their risk of complications. The aim of this systematic review was to compare the effectiveness of multidisciplinary care intervention with that of conventional physical therapy in mitigating kinesiophobia in patients with knee osteoarthritis undergoing joint replacement.

methodsThis study was registered with the International Prospective Register of Systematic Reviews (registration no. CRD42022366356). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, two Chinese databases (the National Digital Library of Theses and Dissertations and Airiti Library) and four English databases (CINAHL, Cochrane Library, PubMed, and Embase) were searched from their inception up to January 2023 for randomized controlled trials (RCTs) on multidisciplinary intervention for kinesiophobia following TKR.

resultsSeven RCTs comprising 648 individuals (327 in the experimental group and 321 in the control group) were included in the analysis. Grading of Recommendations, Assessment, Development, and Evaluations revealed moderate evidence quality and strong recommendations for kinesiophobia, pain, and knee joint functional scales. Meta-analysis revealed that multidisciplinary care intervention significantly outperformed conventional physical therapy in terms of reducing kinesiophobia (P < 0.01), with this effect persisting for up to 6 months after the intervention. The overall effect size (standardized mean difference = -2.57, 95% confidence interval [-3.71, -1.44], P < 0.00001) was large, and no risk of publication bias was found.

conclusionsMultidisciplinary care intervention reduces kinesiophobia in patients with knee osteoarthritis following TKR. It also reduces their pain scores and promotes early postoperative ambulation. Two studies of the seven included RCTs had small sample sizes (fewer than 100 individuals); this may have affected the robustness of the findings.

Indexed as

KinesiophobiaMultidisciplinary interventionTotal knee replacement

Identifiers

PMID40770481
PMCPMC12328877

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.