ArticleMolecular neurobiology2025
Downregulation of Glycogen Synthase Kinase-3 Beta by Urtica dioica L. Contributes to Neuroprotection Against Aluminum Chloride-Mediated Neurotoxicity in Zebrafish Larvae.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Punica granatum L. peel extract mitigates hyperlipidemia-induced cognitive impairments in zebrafish larvae via modulating LXR signaling.Metabolic brain disease · 2026Article
- Clemastine ameliorates ulcerative colitis-induced cognitive impairment by restoring PI3K/Akt/GSK-3β signaling and suppressing ferroptosis.Inflammopharmacology · 2026Article
- Zebrafish as a Model Organism to Study Neurotoxicity: A Potential Tool for Neuroprotective Drug Discovery.Current drug metabolism · 2026Review
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Authors and funding
4 authors.
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Abstract
Urtica dioica L. (U. dioica; Family Urticaceae) has been utilized since ancient times, both as a nutritional source and for its therapeutic properties in addressing multiple disease conditions. The present study aimed to assess the neuroprotective effect of a hydroalcoholic U. dioica leaf extract (Ud) in a zebrafish larva model of aluminum-induced neurotoxicity. The phytochemical quantification of Ud was performed using a high-performance liquid chromatography (HPLC) photodiode array detection method, and the molecular interactions of the identified compounds were studied using in silico docking simulations. Zebrafish embryos were exposed to aluminum chloride (AlCl
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