Evidence map›Paper›PMID 40770431›Full record

ArticleCardiovascular and interventional radiology2025

Genicular Artery Embolization using an Ethiodized Oil-based Emulsion in Fifty Knees: 12-Month Results.

Marc Sapoval, Axel Boyer, Carole Déan, Olivier Pellerin, Alessandro Di Gaeta, Marc Al Ahmar, Xavier Guerra, Helena Pereira, François Rannou, Tom Boeken

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In one paragraph

Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marc SapovalDepartment of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France. marc.sapoval@gmail.com.ORCID http://orcid.org/0000-0003-4226-6192
Axel BoyerDepartment of Radiology, CH Citadelle, Liège, Belgium.
Carole DéanDepartment of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Olivier PellerinDepartment of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Alessandro Di GaetaDepartment of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Marc Al AhmarDepartment of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Xavier GuerraDepartment of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Helena PereiraCentre d'investigation Clinique 1418 Épidémiologie Clinique, INSERM, Paris, France.
François RannouService de Rééducation Et de Réadaptation de L'Appareil Locomoteur Et Des Pathologies du Rachis, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Paris, France.
Tom BoekenDepartment of Vascular and Oncological Interventional Radiology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.

Funding

Guerbet 2024-GFDM-EG01
6 · The paper itself

Abstract

purposeThe purpose of the study was to evaluate the mid-term efficacy of genicular artery embolization (GAE) using an ethiodized oil-based emulsion for the treatment of symptomatic knee osteoarthritis. MATERIALS AND

methodsThis was a single-arm, open-label, single-center, prospective cohort study. Inclusion criteria were GAE using an ethiodized oil-based emulsion for primary knee osteoarthritis. Exclusion criteria were absence of available follow-up longer than 3 months. Clinical efficacy was assessed using the Visual Analog Scale (VAS) pain score and the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) scores.

resultsFifty consecutive GAEs in 46 patients (mean age, 67.4 years ± 9.8) with Kellgren-Lawrence grade from 2 to 4 knee osteoarthritis were included between March 2021 and November 2023. Technical success rate was 100%. No patient experienced complication in the target knee. Mean VAS pain score improved significantly from 71.8 mm ± 16.6 (Standard Deviation [SD]) at baseline to 36.8 mm ± 25.9 at 6 months (n = 41; p < 0.001) and to 37.8 mm ± 26.7 at 12 months (n = 37; p < 0.01). Mean WOMAC index score decreased significantly from 52.7 ± 17.6 at baseline to 30.9 ± 21.8 at 6 months (n = 37; p < 0.001) and to 29.0 ± 20.5 at 12 months (n = 33; p < 0.001). At 12 months, 45.9% (17/37) of the participants reached an acceptable symptom state defined by a VAS pain score < 32.3 mm.

conclusionGenicular artery embolization for symptomatic knee osteoarthritis using an ethiodized oil-based emulsion is safe and improves pain and function with a sustained efficacy at 12 months.

Indexed as

Embolization, TherapeuticEthiodized OilOsteoarthritis, KneeAgedFemaleHumansMaleMiddle AgedPain MeasurementProspective StudiesTreatment OutcomeEthiodized OilEthiodized oil-based emulsionGenicular artery embolizationKnee osteoarthritisPainTransient embolic agent

Identifiers

PMID40770431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.