ArticleCommunications biology2025
Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in 3xTg Alzheimer's model mice.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute cognitive effects of interruptions to prolonged sitting with brief standing or physical activity breaks: a systematic review and three-level meta-analysis.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Retinal Layer Changes With Aging and Cognitive Decline in Rhesus Macaques.Translational vision science & technology · 2026Article
- Exercise and neural circuit stability in early Alzheimer's disease: evidence across memory, executive, cholinergic, and circadian systems.Frontiers in aging neuroscience · 2026Review
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Executive dysfunction encompasses altered decision-making, attentional deficits, excessive risk-taking behaviours, and inefficient planning. Alongside memory loss, these cognitive deficits are amongst the most frequently reported symptoms of Alzheimer's disease (AD). Normal executive function depends on connectivity between the ventral hippocampus and medial prefrontal cortex (mPFC), yet abnormalities in this circuit and how such changes lead to cognitive dysfunction in AD have yet to be fully elucidated. Here, we show that 6-month-old male 3xTg AD mice display maladaptive decision-making in the rodent 4-Choice Gambling Task measure of executive function. Extracellular field recordings in the infralimbic cortex of age-matched 3xTg mice show layer-specific reductions in response amplitude and paired-pulse ratio compared to controls following activation of hippocampal input fibres, indicating changes to short-term hippocampal-prefrontal synaptic plasticity. These results therefore reveal a pre-clinical deficit in executive function that correlates with mPFC synaptic plasticity deficits in a mouse model for AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.