Trial reportBMC surgery2025
Effects of intraoperative open-lung strategy on cardiopulmonary function in frail elderly patients undergoing laparoscopic surgery: a randomized controlled trial.
Trial report in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2026Pooled it
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeThis study aimed to investigate the potential effects of intraoperative open-lung strategy (OLS) on pulmonary function and cardiac function in elderly frail patients.
methods104 frail elderly patients were randomly assigned into non-OLS group [small tidal volume (VT) + 5 cm H2O positive end-expiratory pressure (PEEP)] and OLS group [small VT + stepwise recruitment maneuvers (RM) + individualized PEEP]. Primary outcomes assessed were intraoperative cardiopulmonary function indices and incidence of postoperative pulmonary complications. Secondary outcomes included postoperative myocardial injury markers and recovery outcomes.
resultsEighty-one patients completed the final analysis. The OLS group showed significant improvements in arterial oxygen pressure (PaO2), PaO₂/FiO₂ ratio, and pulmonary dynamic compliance (Cdyn) from the peak of lung recruitment to the end of surgery (T1-T4). The overall incidence of postoperative pulmonary complications (PPCs) also significantly decreased (P<0.05). Compared with the non-OLS group, left ventricular ejection fraction (LVEF), stroke volume (SV), early mitral inflow velocity to early mitral annular velocity ratio (E/E ‘), left ventricular global longitudinal strain (LVGLS), and plane systolic offset of mitral and tricuspid annular plane were significantly decreased at T1 in the OLS group (P<0.05), and recovered at T3. No significant change in the expression of myocardial injury markers between the two groups (P > 0.05). The postoperative recovery outcomes of OLS patients was significantly shortened (P<0.05).
conclusionThe application of OLS can effectively improve intraoperative respiratory mechanics and oxygenation in frail elderly patients, reduce the occurrence of PPCs, and shorten hospital stays of patients, without continuous negative impact on cardiac function.
trial registrationRetrospectively registered; Chinese Clinical Trial Registry, www.chictr.org.cn , number: ChiCTR2200058783; Registered on April 17, 2022.
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