Evidence map›Paper›PMID 40770335›Full record

ArticleJournal of translational medicine2025

Letter to editor: SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer.

Xiaoman Zhang, Yipeng Cong, Xu Zheng, Guangzhen Wu

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaoman Zhang *Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning, China.
Yipeng Cong *Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning, China.
Xu ZhengCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China. zhengxu@dmu.edu.cn.ORCID 0000-0001-5705-0381
Guangzhen WuDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning, China. wuguang0613@hotmail.com.

Funding

Dalian Life and Health field Guidance Plan 2024ZDJH01PT068Liaoning Provincial Education Department JYTMS20230577
6 · The paper itself

Abstract

We are writing to commend the recent article by Zhuang et al. titled "SIGMAR1 screened by a GPCR-related classifier regulates endoplasmic reticulum stress in bladder cancer," published in the Journal of Translational Medicine. This is a highly innovative and clinically significant article that seamlessly integrates bioinformatics and functional analysis to identify SIGMAR1 as a key regulator of endoplasmic reticulum (ER) stress in bladder cancer (BC). Additionally, it establishes a GPCR-tumor microenvironment (TME) classification system combining 15 GPCRs and five immune cell types, offering a novel perspective on traditional clinical treatment research directions. We offer some constructive suggestions here, hoping that our ideas can contribute to a more comprehensive understanding of the mechanisms of SIGMAR1 in BC progression. We sincerely appreciate the time and effort you have invested in this research.

Indexed as

Endoplasmic Reticulum StressReceptors, G-Protein-CoupledSigma-1 ReceptorUrinary Bladder NeoplasmsAnimalsHumansTumor MicroenvironmentOPRS1 protein, humanReceptors, G-Protein-CoupledSigma-1 ReceptorBladder cancerEndoplasmic reticulum stressGPCR-TME classifierSIGMAR1

Identifiers

PMID40770335
PMCPMC12330089

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.