Evidence map›Paper›PMID 40770333›Full record

ArticleBMC surgery2025

Evaluation of risk factors for poor wound healing after cesarean delivery in patients with gestational diabetes mellitus: a retrospective study.

Yan Liu, Ye Wang, Shao-Hua Gao, Hui Wu, Chun-Yu Zhang, Jia-Li Yao, Pei-Xia Cai

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Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Yan LiuDepartment of Obstetrics, Ningbo Mingzhou Hospital Co., Ltd, No. 168, Taian West Road, Yinzhou District, Ningbo city, 315000, Zhejiang Province, China.
Ye WangDepartment of Obstetrics, Ningbo Mingzhou Hospital Co., Ltd, No. 168, Taian West Road, Yinzhou District, Ningbo city, 315000, Zhejiang Province, China.
Shao-Hua GaoDepartment of Obstetrics, Ningbo Mingzhou Hospital Co., Ltd, No. 168, Taian West Road, Yinzhou District, Ningbo city, 315000, Zhejiang Province, China.
Hui WuXiaying Community Health Center, Yinzhou District, Hexi Village, Yinzhou District, Ningbo city, 315105, Zhejiang Province, China.
Chun-Yu ZhangDepartment of Obstetrics, Ningbo Mingzhou Hospital Co., Ltd, No. 168, Taian West Road, Yinzhou District, Ningbo city, 315000, Zhejiang Province, China.
Jia-Li YaoDepartment of Obstetrics, Ningbo Mingzhou Hospital Co., Ltd, No. 168, Taian West Road, Yinzhou District, Ningbo city, 315000, Zhejiang Province, China.
Pei-Xia CaiDepartment of Obstetrics, Ningbo Mingzhou Hospital, No. 168, Taian West Road, Yinzhou District, Ningbo city, 315000, Zhejiang Province, China. PeiXiaCai4692@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor wound healing (PWH) are significant complications following cesarean deliveries, particularly in patients with gestational diabetes mellitus (GDM) due to hyperglycemia-induced immune dysfunction and impaired wound healing. Identifying specific risk factors is essential for developing effective preventive strategies and improving maternal outcomes.

methodsThis retrospective study, conducted from January 2020 to August 2023, followed STROBE guidelines. A total of 268 GDM patients who underwent cesarean delivery were included, with 5 lost to follow-up, yielding a 98.2% follow-up rate. Patients were divided into two groups: the PWH group (n = 26) and the control group (n = 242). Comprehensive data on maternal age, gestational age, pre-pregnancy BMI, IVF-ET use, uterine scarring, surgery type (emergency vs. elective), operative time, and infections (Candida albicans and Group B Streptococcus) were collected. Statistical analyses included Chi-square, Fisher's exact tests, and multivariate logistic regression to identify independent risk factors for PWH.

resultsThe overall incidence of PWH was 9.7%, with the majority being superficial infections, including suture reactions (38.5%), bleeding and exudation (30.8%), abscesses (15.4%), and fat liquefaction (11.5%). Deep infections were rare, with only 3.8% presenting as endometritis and no cases of pelvic abscess. Multivariate logistic regression identified the following significant independent risk factors for PWH: premature rupture of membranes (OR = 10.88, 95% CI: 1.70-71.25, P = 0.002), Candida infection (OR = 5.77, 95% CI: 1.89-18.65, P = 0.003), emergency cesarean delivery (OR = 2.32, 95% CI: 1.02-5.48, P = 0.047), a scarred uterus (OR = 3.68, 95% CI: 1.43-9.39, P = 0.006), and prolonged operative time (≥ 1 h; OR = 2.55, 95% CI: 1.02-3.73, P = 0.031).

conclusionsProlonged operative time, premature rupture of membranes (PROM), emergency cesarean delivery, and uterine scarring were identified as independent risk factors for PWH in GDM patients. Candida infection also showed a statistical association but was based on limited case numbers and should be interpreted cautiously. Targeted perioperative strategies may help reduce PWH risk in this population.

Indexed as

Cesarean SectionDiabetes, GestationalPostoperative ComplicationsWound HealingAdultFemaleHumansPregnancyRetrospective StudiesRisk FactorsSurgical Wound InfectionCesarean deliveryEmergency cesareanGestational diabetes mellitusPoor wound healingRisk factors

Identifiers

PMID40770333
PMCPMC12326777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.