ArticleBMC complementary medicine and therapies2025
The effects of Songling Xuemaikang capsule on vascular remodeling of stage 1 hypertension: a multicenter, randomized placebo-controlled trial protocol.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06093932 (Efficacy of Songling Xuemaikang Capsules on Grade 1 Hypertension), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Songling Xuemaikang Capsules on Grade 1 Hypertension: a Randomized, Multicenter, Double-blind, Placebo-controlled Trial
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Effect of traditional Chinese medicine on sleep and blood pressure in patients with comorbid hypertension-insomnia: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundVascular remodeling (VR), such as arterial stiffness and atherosclerosis (AS), is general pathological characters in the progression of hypertension. It is urgent to develop therapeutic strategies for VR in the progression of hypertension. Songling Xuemaikang capsule (SXC), a Chinese patent medicine, has been preliminarily demonstrated the benefits of lowering blood pressure (BP) and associated hypertensive symptoms. We further investigate the efficacy of SXC in treating the early stages of stage 1 hypertension and the mechanism among SXC, BP and VR.
methodsThis study is designed as a prospective, multicenter, double-blinded, randomized controlled trial. One hundred eligible patients with stage 1 hypertension will be randomly allocated 1:1 into the SXC or placebo treatment for 12 weeks. All individuals were required to follow a healthy lifestyle checklist throughout the process. The primary endpoint is 24-hour ambulatory systolic BP. Secondary endpoints include brachial-ankle pulse wave velocity, skin capillary density, 24-h ambulatory diastolic BP, daytime and nighttime average BP, and other efficacy indicators. The gut microbiome-metabolome profile was analyzed to explore therapeutic mechanisms.
conclusionsThis study will determine the clinical efficacy of SXC on stage 1 hypertension and obtain the possible therapeutic mechanism of SXC on BP and VR, supporting the evidence for traditional Chinese medicine intervention in the development of hypertension.
trial registrationThe study was registered on ClinicalTrials.gov (no. NCT06093932) on October 23, 2023.
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