ArticleBMC cardiovascular disorders2025
Unfavorable influence of amlodipine combined with metoprolol on the short-term prognosis in hypertensive heart failure patients.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate the impact of amlodipine combined with metoprolol and amlodipine alone on the prognosis of patients with hypertensive heart failure.
methodsData were extracted from the MIMIC-IV database. The influence of drug use on patient prognosis was explored by the Chi-square test and Kaplan-Meier analysis. Prognostic analyses initially found that drug use was only associated with short-term prognosis. To further explore the relationship between drug use and short-term prognosis, linear and logistic regression analyses were conducted, adjusting for confounding factors. Subgroup analyses and interaction effect analyses were performed for potential factors that may influence the short-term prognosis. The XG Boots model was employed to assess the importance of drug use on the short-term prognosis of patients.
resultsThe study included 1546 hypertensive heart failure patients with a median age of 72 (62,82) years. Short-term prognosis, such as length of hospital stay, was longer in amlodipine combined with metoprolol patients than in amlodipine alone (6.764 days vs. 5.593 days, P < 0.001). The relationship was also observed in the five models constructed by linear or logistic regression analysis (all P < 0.05). Subgroup and interaction analyses, adjusted for other confounding factors, further confirmed the association between drug use and length of hospital stay. And the results of the XG Boots model displayed that drug use was important among many factors influencing the length of hospital stay.
conclusionAmlodipine combined with metoprolol appeared to have an unfavorable influence on the short-term prognosis of hypertensive heart failure patients.
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