ArticleThe journal of headache and pain2025
Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis.
Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Causal proteomic insights into drug target discovery for tension-type headache.The journal of headache and pain · 2025Article
- Association between psychological disorders and migraine in young U.S. adults with gender-specific analysis and marital status considerations.The journal of headache and pain · 2025Article
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13 authors.
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Abstract
backgroundThe hypothalamus is a versatile structure comprising several nuclei that play key roles in regulating various biological processes associated with migraine, including hormone secretion, metabolism, circadian rhythm, and autonomic nervous system functions. However, the involvement of hypothalamic subregions in migraine remains unclear.
methodsBased on T1-weighted MRI data from 76 migraine patients (23 episodic migraine [EM], 53 chronic migraine [CM]) and 35 healthy controls (HCs), we examined group differences in the volume of five hypothalamic subregions. To clarify causal relationships between migraine and hypothalamic volume, we conducted Mendelian randomization (MR) analyses. Mediation analysis was further performed to assess the role of gut microbiota composition in this association.
resultsCompared to HCs, migraine patients exhibited significantly reduced total hypothalamic volume (813.53 ± 66.46 mm³ vs. 831.86 ± 57.91 mm³; FDR q = 0.048) and inferior tuberal hypothalamic volume (255.26 ± 30.17 mm³ vs. 265.29 ± 23.32 mm³; FDR q = 0.046). These reductions were particularly pronounced in patients with CM, whereas no significant differences were observed in those with EM. MR analysis revealed causal effects of total hypothalamic volumes (OR = 0.80, FDR q = 7.28 × 10
conclusionsThis study suggests that atrophy of the inferior tuberal subregion of the hypothalamus plays a pivotal role in increasing migraine risk, and that this effect is partially mediated through alterations in gut microbiome composition.
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