Evidence map›Paper›PMID 40770227›Full record

ArticleScientific reports2025

Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependent.

Yuuki Obata, Miyuki Natsume, Isamu Shiina, Tsuyoshi Takahashi, Toshirou Nishida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuuki ObataLaboratory of Intracellular Traffic & Oncology, National Cancer Center Research Institute, Tsukiji, 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan. yuobata@ncc.go.jp.
Miyuki NatsumeLaboratory of Intracellular Traffic & Oncology, National Cancer Center Research Institute, Tsukiji, 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.
Isamu ShiinaDepartment of Applied Chemistry, Faculty of Science, Tokyo University of Science, Shinjuku-ku, Tokyo, 162-8601, Japan.
Tsuyoshi TakahashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan.
Toshirou NishidaNational Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A constitutively active mutant of the receptor protein tyrosine kinase KIT is a major cause of gastrointestinal stromal tumours (GISTs). Recently, we discovered that, during biosynthetic transport, the KIT mutant (KIT

Indexed as

Gastrointestinal NeoplasmsGastrointestinal Stromal TumorsGolgi ApparatusPhospholipase DProto-Oncogene Proteins c-kitCell Line, TumorHumansMutationPhospholipase C gammaSignal Transductiontrans-Golgi NetworkKIT protein, humanPhospholipase C gammaPhospholipase Dphospholipase D1phospholipase D2Proto-Oncogene Proteins c-kitGISTGolgi/TGNKITPKDPLDRTK

Identifiers

PMID40770227
PMCPMC12328827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.