Evidence map›Paper›PMID 40770187›Full record

ArticleCell death & disease2025

TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis.

Donatella Delle Cave, Annalisa Di Domenico, Marco Fantuz, Marianna Ciotola, Maria Mangini, Silvia Buonaiuto, Brunella Corrado, Marco Corona, Federica Saracino, Gennaro Andolfi and 10 more

Abstract read
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Donatella Delle Cave *Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. donatella.dellecave@igb.cnr.it.ORCID http://orcid.org/0000-0002-4019-2778
Annalisa Di DomenicoInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Marco FantuzDepartment of Biology, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0001-7758-3660
Marianna CiotolaInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Maria ManginiInstitute of Endotypes in Oncology, Metabolism and Immunology "G. Salvatore" (IEOMI), Second Unit, Naples, Italy.
Silvia BuonaiutoInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Brunella CorradoInterdisciplinary Research Centre on Biomaterials, University of Naples Federico II, Naples, Italy.
Marco CoronaInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Federica SaracinoInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Gennaro AndolfiInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Ilaria Di BiaseInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Antonio CucciardiInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Alessandro CarrerDepartment of Biology, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-9300-6879
Bruno SainzDepartment of Cancer, Instituto de Investigaciones Biomedicas Sols-Morreale (IIBM), CSIC-UAM, Madrid, Spain.ORCID http://orcid.org/0000-0003-4829-7651
Teresa PirozziInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Daniele Lo ReDepartamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, Granada, Spain.
Vincenza ColonnaInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.
Gabriella MinchiottiInstitute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy.ORCID http://orcid.org/0000-0003-0225-9043
Anna Chiara De LucaInstitute of Endotypes in Oncology, Metabolism and Immunology "G. Salvatore" (IEOMI), Second Unit, Naples, Italy.ORCID http://orcid.org/0000-0002-3696-8465
Enza Lonardo *Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' (IGB), CNR, Naples, Italy. enza.lonardo@igb.cnr.it.ORCID http://orcid.org/0000-0001-6654-1043

Funding

Fondazione Italiana per la Ricerca sul Cancro (Italian Foundation for Cancer Research) 21420Fondazione Italiana per la Ricerca sul Cancro (Italian Foundation for Cancer Research) 23029Fondazione Italiana per la Ricerca sul Cancro (Italian Foundation for Cancer Research) 27012Fondazione Italiana per la Ricerca sul Cancro (Italian Foundation for Cancer Research) 30710World Cancer Research Fund (WCRF UK) 20-0188
6 · The paper itself

Abstract

The highly fibrotic microenvironment of pancreatic ductal adenocarcinoma (PDAC) poses significant challenges for effective treatment, particularly in drug delivery and tumor progression. Our study investigates the role of collagen dynamics in PDAC, revealing that TGF-β1 negatively regulates the expression of L1 cell adhesion molecule (L1CAM), leading to a more invasive tumor phenotype. We identify a subset of PDAC cells with low L1CAM expression (L1

Indexed as

Carcinoma, Pancreatic DuctalCollagenMatrix Metalloproteinase 2Neural Cell Adhesion Molecule L1Pancreatic NeoplasmsTransforming Growth Factor beta1AnimalsCell Line, TumorCell MovementDeoxycytidineDown-RegulationGene Expression Regulation, NeoplasticHumansMiceMice, NudeNeoplasm InvasivenessCollagenDeoxycytidineMatrix Metalloproteinase 2MMP2 protein, humanNeural Cell Adhesion Molecule L1Transforming Growth Factor beta1

Identifiers

PMID40770187
PMCPMC12328658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.