Evidence map›Paper›PMID 40770176›Full record

ArticleCell death discovery2025

RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation.

Francesca Romana Liberati, Sharon Spizzichino, Sara Di Russo, Giulia Elizabeth Borsatti, Agnese Riva, Maria Chiara Magnifico, Amani Bouzidi, Giorgio Giardina, Marzia Arese, Chiara Scribani Rossi and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Francesca Romana Liberati *Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Sharon Spizzichino *Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Sara Di Russo *Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Giulia Elizabeth BorsattiDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Agnese RivaDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Maria Chiara MagnificoDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Amani BouzidiDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Giorgio GiardinaDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-0802-1370
Marzia AreseDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Chiara Scribani RossiDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Dalila BoiIstituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, c/o Sapienza University of Rome, Rome, Italy.
Giovanna BoumisDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-5323-7288
Federica Di FonzoDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Giulia GuarguagliniIstituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, c/o Sapienza University of Rome, Rome, Italy.
Roberto ContestabileDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-5235-9993
Angela TramontiIstituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, c/o Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-5625-1170
Alberto MaconeDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.
Alessandro PaiardiniDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-9078-7545
Serena RinaldoDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0003-0682-023X
Alessio PaoneDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy. alessio.paone@uniroma1.it.ORCID http://orcid.org/0000-0001-9406-3982
Francesca CutruzzolàDepartment of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Rome, Italy. francesca.cutruzzola@uniroma1.it.ORCID http://orcid.org/0000-0002-4621-2135

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) 2022KC3X9LSapienza Università di Roma (Sapienza University of Rome) AR22419078021B75Sapienza Università di Roma (Sapienza University of Rome) RM12117A5BDD4AECSapienza Università di Roma (Sapienza University of Rome) RP12117A675EDA46
6 · The paper itself

Abstract

Targeting metabolic reprogramming is crucial for cancer treatment. Recent advances highlight RNA's ability to directly regulate enzyme activity through riboregulation. In this study, we used an RNA-based approach to inhibit the mitochondrial enzyme Serine hydroxymethyltransferase 2 (SHMT2), which lacks a selective in vivo inhibitor. SHMT2, often overexpressed in various cancers, is pivotal in one-carbon metabolism, a pathway vital for cell proliferation. Our results show that RNA effectively inhibits SHMT2's serine-to-glycine conversion in vitro (IC

Identifiers

PMID40770176
PMCPMC12328718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.