Evidence map›Paper›PMID 40770106›Full record

ArticleNature2025

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis.

Vincent R Graziano, Jennifer Porat, Marie Dominique Ah Kioon, Ivana Mejdrová, Alyssa J Matz, Charlotta G Lebedenko, Peiyuan Chai, John V Pluvinage, Rafael Ricci-Azevedo, Andrew G Harrison and 11 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026
    Review
  2. Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Sialylation in the nervous system: Functions and mechanisms.The Journal of biological chemistry · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Mapping GlycoRNAs on an Exosomal Surface.Journal of the American Chemical Society · 2026
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Vincent R GrazianoDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.
Jennifer PoratStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-1709-4635
Marie Dominique Ah KioonHSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0003-2319-0444
Ivana MejdrováDepartment of Chemistry, Institute of Chemical Epigenetics-Munich (ICE-M), Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.
Alyssa J MatzDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.
Charlotta G LebedenkoStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Peiyuan ChaiStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
John V PluvinageDepartment of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0002-9607-2783
Rafael Ricci-AzevedoDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.ORCID 0000-0002-0020-6530
Andrew G HarrisonDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.
Skylar S WrightDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.ORCID 0000-0002-1341-5710
Xinzheng WangDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.
Madison S StrineDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8572-1314
Penghua WangDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.ORCID 0000-0002-7332-1871
Michael R WilsonDepartment of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0002-8705-5084
Sivapriya Kailasan VanajaDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.ORCID 0000-0001-6188-2869
Beiyan ZhouDepartment of Immunology, UConn Health School of Medicine, Farmington, CT, USA.ORCID 0000-0003-0638-2428
Franck J BarratHSS Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0002-0735-0850
Thomas CarellDepartment of Chemistry, Institute of Chemical Epigenetics-Munich (ICE-M), Ludwig-Maximilians-Universität (LMU) München, Munich, Germany.ORCID 0000-0001-7898-2831
Ryan A Flynn *Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. Ryan.Flynn@childrens.harvard.edu.ORCID 0000-0001-5013-0442
Vijay A Rathinam *Department of Immunology, UConn Health School of Medicine, Farmington, CT, USA. Rathinam@uchc.edu.ORCID 0000-0002-8009-3977

Funding

Cytosolic Immune Surveillance During Bacterial InfectionsR01AI119015 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RATHINAM, VIJAY · 2016 to 2025
$4.0M
Host-derived extracellular vesicles in inflammatory caspase activationR01AI148491 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RATHINAM, VIJAY · 2020 to 2024
$2.0M
MiR-150 regulated adiose tissue B cells in obesityR01DK121805 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T, ZHOU, BEIYAN · 2020 to 2024
$2.0M
Bacterial modulation of noncanonical inflammasomeR01AI132850 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KAILASAN VANAJA, SIVAPRIYA · 2018 to 2022
$2.0M
Mechanisms and functions of cell surface glycoRNAsR35GM151157 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI Ryan Alexander Flynn · 2023 to 2026
$1.8M
ASCVD risk assessment in T2DM facilitated by novel computational immunology programsR01HL172239 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Anthony T Vella, Beiyan Zhou · 2024 to 2026
$1.6M
Innate immune roles of glycoRNAF31AI178967 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAZIANO, VINCENT ROBERT · 2024 to 2025
$63k
NHLBI NIH HHS R01 HL172239NIAID NIH HHS F31 AI178967NIAID NIH HHS R01 AI119015NIAID NIH HHS R01 AI132850NIAID NIH HHS R01 AI148491NIDDK NIH HHS R01 DK121805NIGMS NIH HHS R35 GM151157
6 · The paper itself

Abstract

Glycosylation is central to the localization and function of biomolecules

Indexed as

HomeostasisImmune EvasionImmunity, InnatePhagocytosisRNAAnimalsApoptosisEfferocytosisEndosomesFemaleGlycosylationHumansInflammationInterferon Type IMaleMiceInterferon Type IPolysaccharidesRNAToll-Like Receptor 7Uridine

Identifiers

PMID40770106
PMCPMC12845878

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.