Evidence map›Paper›PMID 40770101›Full record

ArticleNature2025

EBV induces CNS homing of B cells attracting inflammatory T cells.

Fabienne Läderach, Ioannis Piteros, Éanna Fennell, Elena Bremer, Mette Last, Sandra Schmid, Lisa Rieble, Caroline Campbell, Isis Ludwig-Portugall, Lea Bornemann and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. EBNA1Neurology(R) neuroimmunology & neuroinflammation · 2026
    Article
  2. Review
  3. Article
  4. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
  5. Immune-mediated excitotoxicity in brain disorders.Nature reviews. Immunology · 2026
    Review
  6. A tonsil organoid model reveals Epstein-Barr virus-infected germinal center B cell states during primary infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Fabienne Läderach *Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Ioannis Piteros *Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Éanna FennellViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID 0000-0002-1280-3439
Elena BremerViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID 0009-0007-5954-7878
Mette LastInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Sandra SchmidViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Lisa RiebleViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID 0000-0001-9773-8607
Caroline CampbellViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Isis Ludwig-PortugallMiltenyi Biotec B.V. & Co. KG, Teterow, Germany.
Lea BornemannMiltenyi Biotec B.V. & Co. KG, Bielefeld, Germany.
Alexander GruhlMiltenyi Biotec B.V. & Co. KG, Bielefeld, Germany.
Klaus EulitzMiltenyi Biotec B.V. & Co. KG, Teterow, Germany.
Paul GueguenFunctional Genomics Center, ETH Zurich/University of Zurich, Zurich, Switzerland.
Juliane MietzCellular Immunotherapy, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID 0009-0007-9359-2242
Anne MüllerViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Gaetana PezzinoDivision of Clinical Pathology, University Hospital Policlinico G.Martino, Messina, Italy.
Jürgen SchmitzMiltenyi Biotec B.V. & Co. KG, Bergisch-Gladbach, Germany.
Guido FerlazzoDivision of Clinical Pathology, University Hospital Policlinico G.Martino, Messina, Italy.
Josef MautnerInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland. christian.muenz@uzh.ch.ORCID 0000-0001-6419-1940

Funding

Swiss National Science Foundation
6 · The paper itself

Abstract

Epidemiological data have identified Epstein-Barr virus (EBV) infection as the main environmental risk factor for multiple sclerosis, the predominant autoimmune disease of the central nervous system (CNS)

Indexed as

B-LymphocytesCell MovementCentral Nervous SystemEpstein-Barr Virus InfectionsHerpesvirus 4, HumanT-LymphocytesAnimalsBrainCD8-Positive T-LymphocytesFemaleHumansInflammationMaleMiceMultiple SclerosisReceptors, CXCR3Cxcr3 protein, mouseReceptors, CXCR3RituximabT-bet Transcription FactorT-Box Domain Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.