ArticleNature2025
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Serum insulin-like growth factor-1 and its association with epilepsy risk and cognitive function.Acta epileptologica · 2026Article
- Single-nucleus transcriptomics reveals cell type-specific remodeling and epilepsy-associated microglia.iScience · 2026Article
- Glial-neuronal crosstalk via GABA signaling: mechanistic insights into neuropsychiatric and neurological pathophysiology.Molecular psychiatry · 2026Review
- Neonatal inflammation disrupts a temporally restricted postnatal Numb-enriched microglial state in mice.Nature communications · 2026Article
- Glucocorticoid Signaling in PSC-Derived Neural Systems to Elucidate Mechanisms of Stress-Induced Psychiatric Vulnerability.Molecular neurobiology · 2026Review
- Article
- The microglia-derived protein Sema4ab attenuates regenerative neurogenesis after spinal cord injury in zebrafish.PLoS biology · 2026Article
- Microglia in systemic neuroimmune communication: functions beyond phagocytosis.Trends in immunology · 2026Review
- Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation.bioRxiv : the preprint server for biology · 2026Article
- Integrated Clinical and Molecular Profiling of Fetal Growth Disorders in the First Trimester.International journal of molecular sciences · 2026Article
- Myeloid compartment reprogramming through nanoparticle-delivered resiquimod blocks paracrine growth support and activates phagocytosis to slow tumor progression in endogenous mouse medulloblastoma and diffuse midline glioma models.bioRxiv : the preprint server for biology · 2026Article
- Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy-Associated Microglia.bioRxiv : the preprint server for biology · 2026Article
- Downregulation of ClC-3 chloride channels in dorsal root ganglia neurons contributes to bone metastasis-induced pain.The Journal of biological chemistry · 2026Article
- Microglia-Neuron Crosstalk: An Intimate Molecular Conversation in Neurodegeneration.International journal of molecular sciences · 2026Review
- Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice.Nature communications · 2026Article
- Insulin and IGF signaling in the brain: multilevel regulation of synaptic and network homeostasis.Frontiers in endocrinology · 2026Review
- The Neurogenic Niche: Interactions Among Vessels, Glia, and Neural Stem Cells.Stem cells international · 2026Review
- Exercise as a multiscale recalibration of stress-related homeostatic balance.Frontiers in neuroscience · 2026Review
- Reprogramming brain-resident macrophages: from disease drivers to therapeutic allies in neurological disorders.Frontiers in cellular neuroscience · 2026Review
- Pluripotent stem cells-based neural organoids for modelling human brain development and diseases.Cell & bioscience · 2025Review
Corrections and comments
- Update of
Authors and funding
13 authors.
Diankun Yu *Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. diankun.yu@ucsf.edu.ORCID 0000-0002-1390-7985
Samhita Jain *Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8777-1865
Andi WangzhouWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5667-1223
Beika ZhuWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Wenyuan ShaoWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0006-7744-5739
Elena J Coley-O'RourkeWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0003-2802-1372
Stacy De FlorencioWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
JaeYeon KimWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0542-9071
Jennifer Ja-Yoon ChoiDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Mercedes F ParedesWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2503-1447
Tomasz J NowakowskiWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Eric J HuangWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5381-3801
Xianhua PiaoWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. xianhua.piao@ucsf.edu.ORCID 0000-0001-7540-6767
Funding
Regulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PIAO, XIANHUA · 2014 to 2024
$12.6MAdhesion G Protein-Coupled Receptors in CNS Development and RegenerationR01NS094164 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PIAO, XIANHUA · 2015 to 2025
$4.5MGlial Mechanisms Of Developmental Synapse RefinementR01NS108446 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PIAO, XIANHUA · 2018 to 2022
$2.9MNeuroinflammation and vascular development in GMHR01NS132595 · NINDS · WASHINGTON UNIVERSITY · PI Eric J Huang · 2023 to 2026
$2.2MProtracted Maturation of Cortical Inhibitory Neurons for the Complexity of Higher Cognitive AreasK99NS138587 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jaeyeon Kim · 2025 to 2026
$231kBLRD VA I01 BX001108NINDS NIH HHS K99 NS138587NINDS NIH HHS P01 NS083513NINDS NIH HHS R01 NS094164NINDS NIH HHS R01 NS108446NINDS NIH HHS R01 NS132595
Abstract
GABAergic neurons are essential cellular components of neural circuits. Their abundance and diversity have increased significantly in the human brain, contributing to the expanded cognitive capacity of humans
Indexed as
BrainGABAergic NeuronsInsulin-Like Growth Factor IMicrogliaNeurogenesisCell ProliferationFemaleHumansMaleNeural Stem CellsOrganoidsReceptor, IGF Type 1Receptors, SomatomedinIGF1 protein, humanIGF1R protein, humanInsulin-Like Growth Factor IReceptor, IGF Type 1Receptors, Somatomedin
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Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.