ArticleNature2026
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- NSD Histone Methyltransferases in Solid Tumors: Biological Functions, Oncogenic Mechanisms and Therapeutic Targeting.International journal of molecular sciences · 2026Review
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2.Journal of medicinal chemistry · 2026Article
- The 2025 lung cancer landscape: advances in screening, molecular taxonomy and therapeutic strategy: a narrative review.Translational lung cancer research · 2026Review
- Regarding Emitter Positioning for Nanoflow Electrospray Ionization with a High-Capacity Inlet Capillary.Journal of the American Society for Mass Spectrometry · 2026Article
- NSD Family-Mediated H3K36 Methylation in Human Cancer: Mechanisms and Therapeutic Opportunities.Biomedicines · 2025Review
- Chromatin Regulatory Targets for Anticancer Therapeutics.Chemical reviews · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors.
Jinho Jeong *Department of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1224-7196
Simone Hausmann *Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-9577-4225
Hanyang Dong *Department of Biology, Stanford University, Stanford, CA, USA.
Kacper Szczepski *Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Natasha M Flores *Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Andy Garcia GonzalezDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID 0009-0003-5829-8014
Liyang ShiDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Xiaoyin LuDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-9244-325X
Joanna LempiäinenDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-6100-5815
Moritz JakabDepartment of Biology, Stanford University, Stanford, CA, USA.
Liyong ZengDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tourkian ChasanDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-9108-2205
Eric BarekeDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-3928-7160
Rui DongDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6782-1186
Emma CarlsonDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Reinnier PadillaDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID 0009-0005-5646-5450
Dylan HusmannDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1995-7892
Julia ThompsonDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Gerry A ShipmanDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-0385-6061
Emily ZahnDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0009-0009-0431-5820
Courtney A BarnesEpiCypher, Durham, NC, USA.
Laiba F KhanEpiCypher, Durham, NC, USA.ORCID 0009-0000-5427-0653
Liz Marie Albertorio-SáezEpiCypher, Durham, NC, USA.ORCID 0000-0003-3419-5849
Eva BrillEpiCypher, Durham, NC, USA.ORCID 0000-0003-2463-0296
Vishnu Udayakumar Sunita KumaryEpiCypher, Durham, NC, USA.
Matthew R MarundeEpiCypher, Durham, NC, USA.
Danielle N MaryanskiEpiCypher, Durham, NC, USA.ORCID 0009-0002-9062-0520
Cheryl C SzanyEpiCypher, Durham, NC, USA.
Bryan J VentersEpiCypher, Durham, NC, USA.
Carolina Lin WindhamEpiCypher, Durham, NC, USA.ORCID 0009-0004-7540-8390
Michal Eligiusz NowakowskiDivision of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Iwona CzabanDivision of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.ORCID 0000-0002-8038-1573
Mariusz JaremkoDivision of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Michael-Christopher KeoghEpiCypher, Durham, NC, USA.ORCID 0000-0002-2219-8623
Kang LeTherapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michael J SothTherapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-3596-4750
Łukasz JaremkoDivision of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. lukasz.jaremko@kaust.edu.sa.ORCID 0000-0001-7684-9359
Jacek MajewskiDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada. jacek.majewski@mcgill.ca.ORCID 0000-0003-3572-9558
Pawel K MazurDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. pkmazur@mdanderson.org.ORCID 0000-0002-5820-8344
Or GozaniDepartment of Biology, Stanford University, Stanford, CA, USA. ogozani@stanford.edu.ORCID 0000-0002-1365-4463
Funding
Therapeutic Targeting of NSD2 in Lung AdenocarcinomaR01CA272844 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Or P. Gozani, Pawel K. Mazur · 2023 to 2026
$2.6MMechanisms of action and therapeutic targeting of the CARM1-NFIB axis in small cell lung cancerR01CA272843 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MARK T. BEDFORD, Pawel K. Mazur · 2023 to 2026
$2.6MRole of NSD3 in regulation of cancer pathogenesisR01CA278940 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Or P. Gozani, Pawel K. Mazur · 2023 to 2026
$2.6MNCI NIH HHS R01 CA272843NCI NIH HHS R01 CA272844NCI NIH HHS R01 CA278940
Abstract
NSD2 catalyses the epigenetic modification H3K36me2 (refs.
Indexed as
ChromatinEnzyme InhibitorsHistone-Lysine N-MethyltransferaseLung NeoplasmsPancreatic NeoplasmsRepressor ProteinsAnimalsCell Line, TumorEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticGene SilencingHistonesHumansMaleMethylationChromatinEnzyme InhibitorsHistone-Lysine N-MethyltransferaseHistonesKRAS protein, humanNSD2 protein, humanProto-Oncogene Proteins p21(ras)Repressor ProteinsS-Adenosylmethionine
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.