Evidence map›Paper›PMID 40770036›Full record

Trial reportScientific reports2025

Feasibility of an unsupervised aerobic exercise training program for participants with persistent symptoms after SARS-CoV-2 infection.

Carina Emmel, Oliver Bruder, Niklas Keller, Lukas Schipper, Christoph Schneider, Alexander Ferrauti, Mirjam Frank, Marcus Brinkmann, Mareike Eißmann, Thimo Wiewelhove and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carina EmmelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Oliver BruderDepartment of Cardiology and Angiology, Elisabeth-Krankenhaus, Essen, Germany.
Niklas KellerDepartment of Fitness and Health, IST University of Applied Sciences, Düsseldorf, Germany.
Lukas SchipperInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Christoph SchneiderDepartment of Cardiology and Angiology, Elisabeth-Krankenhaus, Essen, Germany.
Alexander FerrautiDepartment of Training & Exercise Science, Ruhr University Bochum, Bochum, Germany.
Mirjam FrankInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Marcus BrinkmannInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany.
Mareike Eißmann *Department of Cardiology and Angiology, Elisabeth-Krankenhaus, Essen, Germany.
Thimo Wiewelhove *Department of Fitness and Health, IST University of Applied Sciences, Düsseldorf, Germany.
Börge Schmidt *Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstraße 55, 45122, Essen, Germany. boerge.schmidt@uk-essen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of the randomized controlled pilot study was to investigate general feasibility in terms of adherence to a 12-week unsupervised aerobic exercise training program in participants with persistent symptoms (fatigue, concentration problems, breathing problems or headache) > 12 months after SARS-CoV-2 infection. Multiple symptom-related, psychosocial, spiroergometric and body composition parameters were collected at baseline and follow-up examination. The intervention group underwent a 12-week unsupervised aerobic exercise training program. The control group kept their regular physical activity. Both groups maintained an online training diary. Data was evaluated descriptively using intention-to-treat, per protocol and as-treated analysis. Feasibility of an unsupervised aerobic exercise training intervention was limited, as a large number of participants in the intervention group did not strictly adhere to the training plan. Therefore, statements about the efficacy were restricted. However, there was some weak indication for efficacy of the intervention to reduce self-rated severity of symptoms and to improve overall wellbeing. In the present study, an unsupervised aerobic exercise training intervention can be recommended only to a limited extend. The study results can be used to inform future studies designed to evaluate the efficacy of unsupervised aerobic exercise training programs in participants with persistent symptoms after SARS-CoV-2 infection.

Indexed as

COVID-19ExerciseExercise TherapyAdultAgedFatigueFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsSARS-CoV-2

Identifiers

PMID40770036
PMCPMC12328756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.