Evidence map›Paper›PMID 40770022›Full record

ArticleScientific reports2025

Uracil derivatives/ursolic acid hybrids - naturally derived compounds as anticancer agents.

Olga Michalak, Marcin Cybulski, Marek Kubiszewski, Nataliya Finiuk, Yuliia Kozak, Dejan Milenkovic, Sylwia Żurawicka, Piotr Roszczenko, Anna Bielawska, Bartosz Trzaskowski and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Naturally Derived SENP1 Inhibitors with Anticancer Activity.International journal of molecular sciences · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Olga MichalakChemistry Section; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str, Warsaw, 01-793, Poland. olga.michalak@ichp.lukasiewicz.gov.pl.
Marcin CybulskiChemistry Section; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str, Warsaw, 01-793, Poland. marcin.cybulski@ichp.lukasiewicz.gov.pl.
Marek KubiszewskiAnalytical Research Section, Pharmaceutical Analysis Laboratory, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str, Warsaw, 01-793, Poland.
Nataliya FiniukInstitute of Cell Biology, National Academy of Sciences of Ukraine, 14/16 Drahomanov Str, Lviv, 79005, Ukraine.
Yuliia KozakInstitute of Cell Biology, National Academy of Sciences of Ukraine, 14/16 Drahomanov Str, Lviv, 79005, Ukraine.
Dejan MilenkovicInstitute for Information Technologies, University of Kragujevac, Jovana Cvijića bb Str, Kragujevac, 34000, Serbia.
Sylwia ŻurawickaChemistry Section; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str, Warsaw, 01-793, Poland.
Piotr RoszczenkoDepartment of Biotechnology, Medical University of Bialystok, 1 Kilińskiego Str, Białystok, 15-089, Poland.
Anna BielawskaDepartment of Biotechnology, Medical University of Bialystok, 1 Kilińskiego Str, Białystok, 15-089, Poland.
Bartosz TrzaskowskiChemical and Biological Systems Simulation Lab, Center of New Technologies, University of Warsaw, 2C Banacha Str, Warsaw, 02-097, Poland.
Agnieszka GornowiczDepartment of Biotechnology, Medical University of Bialystok, 1 Kilińskiego Str, Białystok, 15-089, Poland.

Funding

Medical University of Bialystok grant No. B.SUB.25.364the Polish Ministry of Science and Higher Education under the framework of a Łukasiewicz-Industrial Chemistry Institute No. 84133301
6 · The paper itself

Abstract

A series of new uracil derivatives/ursolic acid hybrids were designed and synthesised as potential cytotoxic agents. The uracil, thymine, 6-methyluracil and 2-thiouracil moieties were linked to ursolic acid (1) through alkyl chains of different lengths (either four or six -CH

Indexed as

Antineoplastic AgentsTriterpenesUracilCell Line, TumorCell ProliferationCell SurvivalHumansMCF-7 CellsMolecular Docking SimulationUrsolic AcidAntineoplastic AgentsTriterpenesUracilUrsolic AcidADMEBreast cancerCytotoxic activityMolecular dockingUracil derivativesUrsolic acid

Identifiers

PMID40770022
PMCPMC12329029

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.