Depression mediates the association between lipid accumulation products and overactive bladder.

Caijuan Huang, Ying Xu, Yibing Guan, Jingjing Liu, Haiping Yang

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Caijuan Huang *Department of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Ying Xu *Department of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Yibing GuanDepartment of Urology, The First Affiliated Hospital of Zhengzhou university, Zhengzhou, China.

Jingjing LiuDepartment of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Haiping YangDepartment of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China. yhphaust@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between lipid accumulation products (LAP) and overactive bladder (OAB) has not been explored. This study aims to investigate the relationship between LAP and OAB and the mediating role of depression. Data from seven cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 were used to analyze the relationship between LAP and OAB. The association between LAP and OAB was estimated using multivariable logistic regression models, and the dose-response relationship was estimated using restricted cubic splines (RCS). In addition, subgroup analysis was also performed. Moreover, important factors associated with OAB were identified by Random Forest (RF). Finally, the extent to which depression mediates the association between LAP and OAB was investigated. A total of 13,861 participants with an average age of 49.65 years were enrolled, including 6,869 females (50%), of which 2,739 were diagnosed with OAB. The age-adjusted prevalence of OAB gradually increased among the quartile groups of LAP. In the fully adjusted model, there was a significant positive association between Ln

Indexed as

DepressionLipid MetabolismUrinary Bladder, OveractiveAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrevalenceRisk FactorsCross-sectional studyDepressionLipid accumulation productsMediation analysis.NHANESOveractive bladder

Identifiers

PMID40770007

DOI10.1038/s41598-025-11401-3

PMCPMC12328613

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