Evidence map›Paper›PMID 40769963›Full record

ArticleTranslational psychiatry2025

Associations between testosterone and future PTSD symptoms among middle age and older UK residents.

Hanyang Shen, Ciera Stafford, Joeri Meijsen, Lijin Zhang, Jacob Reiter, Rebecca B Lawn, Alicia K Smith, Mytilee Vermuri, Laramie E Duncan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanyang ShenDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3273-9777
Ciera StaffordDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0009-1438-474X
Joeri MeijsenDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4161-2199
Lijin ZhangGraduate School of Education, Stanford University, Stanford, CA, USA.
Jacob ReiterDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Rebecca B LawnDepartment of Epidemiology at the Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Alicia K SmithDepartment of Gynecology and Obstetrics, Department of Psychiatry and Behavioral Sciences, Department of Human Genetics, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8537-5156
Mytilee VermuriDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0003-0847-4825
Laramie E DuncanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. Laramied@stanford.edu.ORCID http://orcid.org/0000-0003-1131-661X

Funding

Sex hormones and post-traumatic stress disorder (PTSD)R01MH123486 · NIMH · STANFORD UNIVERSITY · PI DUNCAN, LARAMIE · 2020 to 2024
$2.1M
Sex Chromosome GWAS of Post-Traumatic Stress Disorder (PTSD)R21MH125358 · NIMH · STANFORD UNIVERSITY · PI DUNCAN, LARAMIE · 2021 to 2022
$443k
NIMH NIH HHS R01 MH123486NIMH NIH HHS R21 MH125358U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01 MH123486 [Duncan]U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21 MH125358 [Duncan]
6 · The paper itself

Abstract

Testosterone has been theorized to influence the development of post-traumatic stress disorder (PTSD). However, the relationship between testosterone level and PTSD is still not well understood. We evaluated the potential association between testosterone and subsequent development of PTSD symptoms using a large sample size, in a civilian context, inclusive of both males and females. Out of around 500,000 total UK Biobank participants, our sample had 130,471 participants who: had testosterone measures, completed the mental health questionnaire, and passed outlier exclusion. After adjusting for relevant covariates, we used linear regression to assess the relationship between testosterone level and future development of symptoms, in males and females separately (N

Indexed as

Stress Disorders, Post-TraumaticTestosteroneAgedFemaleHumansLinear ModelsMaleMiddle AgedRisk FactorsSurveys and QuestionnairesUK BiobankUnited KingdomTestosterone

Identifiers

PMID40769963
PMCPMC12328684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.