Evidence map›Paper›PMID 40769904›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Tocilizumab for Rheumatoid Meningitis in Elderly Patients: A Report of Two Cases.

Kazuhiro Horiuchi, Shuntaro Nakamura, Kazuki Yamada

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kazuhiro HoriuchiDepartment of Neurology, Hakodate Municipal Hospital, Japan.
Shuntaro NakamuraDepartment of Neurology, Hakodate Municipal Hospital, Japan.
Kazuki YamadaDepartment of Neurology, Hakodate Municipal Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid meningitis (RM), a rare neurological complication of rheumatoid arthritis (RA), presented as hypertrophic pachymeningitis and leptomeningitis in two octogenarian patients. Case 1 had established RA, while Case 2 was diagnosed with RA after neurological onset. Both patients initially received high doses of corticosteroids. Due to age and the need for steroid sparing, tocilizumab was administered. Both showed significant clinical and radiological improvements, allowing for successful corticosteroid tapering. Tocilizumab appears to be effective for RM, especially in elderly patients, as it mitigates the risks associated with long-term corticosteroid use.

Indexed as

Antibodies, Monoclonal, HumanizedArthritis, RheumatoidMeningitisAged, 80 and overFemaleHumansMaleTreatment OutcomeAntibodies, Monoclonal, Humanizedtocilizumabelderly-onset rheumatoid arthritishypertrophic pachymeningitisrheumatoid arthritisrheumatoid meningitistocilizumab

Identifiers

PMID40769904
PMCPMC13018999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.