ArticleVox sanguinis2025
Manufacturing stresses do not differentially impact red blood cells from donors with diabetes.
Article in Vox sanguinis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Manufacturing stresses do not differentially impact red blood cells from donors with diabetes.Vox sanguinis · 2025Article
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8 authors.
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Abstract
BACKGROUND AND
objectivesWith the rising prevalence of diabetes and expanded blood donor criteria in Canada, individuals with diabetes are increasingly contributing to the blood supply. However, little is known about how routine manufacturing affects red blood cells (RBCs) from this group. This study examined RBC differences in donors with type 1 (T1D) or type 2 diabetes (T2D) following processing to generate red cell concentrates (RCCs). MATERIALS AND
methodsWhole blood (WB) donations were collected from voluntary T1D (n = 12), T2D (n = 11) and non-diabetic age/sex-matched (n = 23) donors. Donations were processed via red cell filtration to generate RCCs. At donation, 2.7-mL of WB was collected into EDTA tubes, and 70 mL of processed RCCs was aliquoted into satellite bags. WB-EDTA tubes and RCC satellite bags were characterized on Day 2 post collection.
resultsDonors with T1D and T2D had similar, but higher glycated haemoglobin (HbA1c) levels than matched controls (p < 0.001). Processing increased RBC count, haemoglobin and haematocrit in all groups (p < 0.0001). Donors with T2D had decreased mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) compared to controls, both pre and post processing (p < 0.05), with a similar trend in p50 (pre: p < 0.01; post: p < 0.05).
conclusionBlood component manufacturing did not exacerbate stress on RBCs from donors with diabetes. Donors with T2D had altered MCH, MCHC and p50 compared to matched controls, which persisted after processing. These findings emphasize the importance of donor health on blood product quality.
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