Evidence map›Paper›PMID 40769519›Full record

ArticleAnimal science journal = Nihon chikusan Gakkaiho

Possible Involvement of CSPG4 in Promoting Endothelial Cell Migration and Contributing to Angiogenesis during Skeletal Muscle Regeneration and Development in the Rat.

Riku Yamaguchi, Masanari Ikeda, Shiho Takeuchi, Katsuyuki Nakamura, Akbota Kurmangaliyeva, Naomi Teramoto, Hidetoshi Sugihara, Chihiro Kikawa, Takashi Matsuwaki, Masugi Nishihara and 1 more

Abstract read
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In one paragraph

Article in Animal science journal = Nihon chikusan Gakkaiho. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Riku YamaguchiLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Masanari IkedaLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Shiho TakeuchiLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Katsuyuki NakamuraDepartment of Chemistry and Biomolecular Science, Biomolecular Science Course, Faculty of Engineering, Gifu University, Gifu, Japan.
Akbota KurmangaliyevaCollege of Medicine and Health Sciences, Khalifa University, Abu Dhabi, UAE.
Naomi TeramotoLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Hidetoshi SugiharaLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Chihiro KikawaLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Takashi MatsuwakiLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Masugi NishiharaLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Keitaro YamanouchiLaboratory of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1491-5127

Funding

Ito FoundationJapan Society for the Promotion of Science 16H05041Japan Society for the Promotion of Science 16J08006Japan Society for the Promotion of Science 20H03161Japan Society for the Promotion of Science 23H00359Japan Society for the Promotion of Science JP24KJ0705
6 · The paper itself

Abstract

Skeletal muscle regeneration is a complex process that requires coordinated interactions between myogenic and vascular cells. Chondroitin sulfate proteoglycan 4 (CSPG4), a cell surface proteoglycan, had been shown to be expressed around immature myofibers in patients with Duchenne muscular dystrophy, suggesting its role in muscle regeneration. In the present study, we found that CSPG4 is transiently expressed by regenerating myofibers upon muscle injury in the rat. We generated the CSPG4 knockout (KO) rats to investigate its role in muscle regeneration. In CSPG4 KO rats, skeletal muscle development was perturbed with impaired angiogenesis. When muscle regeneration was induced, CSPG4 KO rats showed a reduced number of CD31-positive cells at the regenerating site. These results suggest the role of CSPG4 in angiogenesis during muscle regeneration and development. In vitro, coculture of CSPG4-expressing mesenchymal progenitor cells (MPC) promoted vascular endothelial cell migration, whereas the KO of CSPG4 in MPC abrogated the upregulation of endothelial cell migration. Our findings identify CSPG4 as a key regulator of vascular endothelial cell recruitment during muscle vascular remodeling and highlight its potential as a therapeutic target for Duchenne muscular dystrophy, which is characterized by impaired angiogenesis.

Indexed as

Cell MovementChondroitin Sulfate ProteoglycansEndothelial CellsMuscle DevelopmentMuscle, SkeletalNeovascularization, PhysiologicProteoglycansRegenerationAngiogenesisAnimalsAntigensCells, CulturedChondroitin Sulfate Proteoglycan 4Gene Knockout TechniquesMaleMesenchymal Stem CellsAntigensChondroitin Sulfate Proteoglycan 4Chondroitin Sulfate ProteoglycansProteoglycansangiogenesischondroitin sulfate proteoglycan4ratregenerationskeletal muscle

Identifiers

PMID40769519
PMCPMC12328044

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.