ArticleNature2025
Microglia-neuron crosstalk through Hex-GM2-MGL2 maintains brain homeostasis.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Review
- Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Article
- Microglia-Mediated Vascular Network Remodeling After Ischemic Stroke: An Immunovascular Repair Framework.Cells · 2026Review
- Congenital Disorders of Glycosphingolipid Biosynthesis: Ultrarare Severe Syndromes or Relatively Frequent Mild Neurocognitive Illnesses?Biomedicines · 2026Article
- CSF1R-related leukoencephalopathy: experimental models and potential for treatment.Disease models & mechanisms · 2026Review
- Physiological levels of 3-hydroxykynurenine alter mitochondrial function and morphology in neuronal cells.bioRxiv : the preprint server for biology · 2026Article
- A transcriptomic microglia taxonomy across mouse and human pathologies.Nature immunology · 2026Article
- The Arp2/3 complex controls the development of homeostatic microglia.EMBO reports · 2026Article
- The Roles of Macrophage Lineage Cells (MLCs) in Brain Aging.CNS neuroscience & therapeutics · 2026Review
- ACSL1-Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microglia-Neuron Crosstalk: An Intimate Molecular Conversation in Neurodegeneration.International journal of molecular sciences · 2026Review
- Glial Cell Dynamics in Neuroinflammation: Mechanisms, Interactions, and Therapeutic Implications.Biomedicines · 2026Review
- Atractylenolide III for central nervous system disorders: a review of multi-target mechanisms and therapeutic potential.Frontiers in pharmacology · 2026Review
- Calycosin attenuates LPS-induced microglia inflammatory responses and microglia-mediated synaptic impairment via modulation of TLR4/MyD88/NF-κB signaling pathway.Frontiers in pharmacology · 2026Article
- Single-Molecule Discrimination of Multisialylated Ganglioside Oligosaccharides Using an Engineered Nanopore.Research (Washington, D.C.) · 2026Article
- Insights gained from single-cell sequencing analysis of ischemic stroke.Frontiers in cell and developmental biology · 2026Review
- Microglia across evolution: from conserved origins to functional divergence.Cellular & molecular immunology · 2025Review
- Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Maximilian FroschInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-5418-0962
Takashi ShimizuInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Emile WogramInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Lukas AmannInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-8363-373X
Lars GruberCenter for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany.ORCID 0009-0009-9955-1550
Ayelén I GroismanInstitute for Physiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-2309-7055
Maximilian FliegaufInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marius SchwabenlandInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-2205-5427
Chintan ChhatbarInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sabrina ZechelDepartment of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
Hendrik RosewichDepartment of Child Neurology, Developmental Neurology, General Pediatrics, Diabetology, Endocrinology, Social Pediatrics, University Hospital Tübingen, Tübingen, Germany.ORCID 0000-0003-4692-5511
Jutta GärtnerDivision of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Georg August University, Göttingen, Germany.
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8156-0736
Joerg M BuescherMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID 0000-0002-6547-0076
Thomas BlankInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3969-405X
Harald BinderInstitute of Medical Biometry and Statistics (IMBI), Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Christine StadelmannDepartment of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0003-1766-5458
Johannes J LetzkusInstitute for Physiology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Carsten HopfCenter for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany.ORCID 0000-0003-0802-6451
Takahiro Masuda *Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID 0000-0003-3687-452X
Klaus-Peter Knobeloch *Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-1587-1944
Marco Prinz *Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.ORCID 0000-0002-0349-1955
Funding
No grant is acknowledged in the PubMed record.
Abstract
As tissue-resident macrophages of the central nervous system parenchyma, microglia perform diverse essential functions during homeostasis and perturbations
Indexed as
beta-N-AcetylhexosaminidasesBrainG(M2) GangliosideLectins, C-TypeMicrogliaNeuronsAnimalsCell CommunicationFemaleHomeostasisHumansLipidomicsMaleMiceSandhoff DiseaseSingle-Cell Analysisbeta-N-AcetylhexosaminidasesG(M2) GangliosideLectins, C-Type
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.