ArticleCell metabolism2025
Glucose-dependent glycosphingolipid biosynthesis fuels CD8
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Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Inhibition of the lipocalin-2-phosphatidylserine axis restores natural killer cell immune surveillance.Cell reports. Medicine · 2026Article
- Nanozyme-Mediated Cellular and Microenvironmental Metabolic Reprogramming for Boosting Cancer Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Glycosphingolipids are essential entry factors for non-influenza orthomyxoviruses.The Journal of general virology · 2026Article
- Implications of Rho GTPase signaling in cancer immunotherapy.Biochemical Society transactions · 2026Review
- Review
- Article
- Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in monocyte-derived macrophages in guillain-barré syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- The pyruvate branch point controls lymphoid cancer cell dissemination.bioRxiv : the preprint server for biology · 2026Article
- Nanomedicine-enabled disruption of glucose metabolism and synergistic antitumor therapy.Journal of nanobiotechnology · 2026Review
- Immunomodulation by glycosylation: bridging glycobiology to adaptive immunity and therapeutic innovation.Frontiers in immunology · 2026Review
- Predictive and mechanistic insights ofPeerJ · 2026Article
- Machine Learning-Guided Multi-Omics Integration Identifies UGCG as a Candidate Lipid Metabolic Biomarker and Potential Therapeutic Target in Sepsis.Journal of inflammation research · 2026Article
- The Role of Lipid Metabolism in the Progression of Breast Cancer.Journal of Cancer · 2026Review
- Glycolytic reprogramming in cancer: immune crosstalk, nutrient competition, and supportive care perspectives.Frontiers in immunology · 2026Review
- Review
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells.Cell · 2025Article
Corrections and comments
- Update of
Authors and funding
22 authors.
Joseph LongoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Lisa M DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Brandon M OswaldDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Robert TeisDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Alfredo Reyes-OliverasDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.
Michael S DahabiehDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Abigail E EllisMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Michael P VincentMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Hannah DamicoBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI, USA.
Kristin L GallikOptical Imaging Core, Van Andel Institute, Grand Rapids, MI, USA.
Nicole M FoyDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Shelby E ComptonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Colt D CapanMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Kelsey S WilliamsDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA; Metabolism and Nutrition Program, Van Andel Institute, Grand Rapids, MI, USA.
Corinne R EsquibelOptical Imaging Core, Van Andel Institute, Grand Rapids, MI, USA.
Zachary B MadajBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI, USA.
Hyoungjoo LeeMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Dominic G RoyCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, QC, Montréal, Canada; Institut du Cancer de Montréal, Montréal, QC, Canada.
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Brian B HaabDepartment of Cell Biology, Van Andel Institute, Grand Rapids, MI, USA.
Ryan D SheldonMass Spectrometry Core, Van Andel Institute, Grand Rapids, MI, USA.
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA; Metabolism and Nutrition Program, Van Andel Institute, Grand Rapids, MI, USA. Electronic address: russell.jones@vai.org.
Funding
Ketone Body Metabolism in CD8+ T Cell ResponsesR01AI165722 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI JONES, RUSSELL GRAHAM · 2022 to 2025
$3.3MDietary regulation of anti-tumor immunity through caloric restrictionU01CA297713 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Russell Graham Jones · 2025 to 2026
$1.5MULK Inhibition Rewires Tumor and Immune Cell MetabolismR01CA297993 · NCI · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Russell Graham Jones, Jeffrey Paul MacKeigan · 2025 to 2026
$1.4MChromatin architecture as a determinant of dendritic cell functionR21AI153997 · NIAID · VAN ANDEL RESEARCH INSTITUTE · PI KRAWCZYK, CONNIE · 2020 to 2021
$523kNCI NIH HHS R01 CA297993NCI NIH HHS U01 CA297713NIAID NIH HHS R01 AI165722NIAID NIH HHS R21 AI153997
Abstract
Glucose is essential for T cell proliferation and function, yet its specific metabolic roles in vivo remain poorly defined. Here, we identify glycosphingolipid (GSL) biosynthesis as a key pathway fueled by glucose that enables CD8
Indexed as
CD8-Positive T-LymphocytesGlucoseGlycosphingolipidsAnimalsMembrane MicrodomainsMiceMice, Inbred C57BLSignal TransductionGlucoseGlycosphingolipidsCD8(+) T cellscytotoxic functionglucoseglycosphingolipidsimmunometabolismlipidomicslipid raftsmetabolomicsnucleotide sugar metabolismUGCG
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.