ArticleJACC. Heart failure2025
Utility of HFpEF Diagnostic Scores to Stratify Cardiac Reserve Among Patients With Dyspnea.
Article in JACC. Heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Phenotypic Characterization of Unclassified Pulmonary Hypertension.Circulation. Heart failure · 2026Observational
- Prognostic value of pretest probability of heart failure with preserved ejection fraction in patients with coronary artery disease: an insight from the CLIDAS-PCI database.Cardiovascular intervention and therapeutics · 2026Article
- Implications of Potential Undiagnosed HFpEF on Symptomatic Response With Coronary Revascularization.JACC. Heart failure · 2026Article
- The diagnosis and subclassification of heart failure with preserved ejection fraction: a review.Heart failure reviews · 2026Review
- Prevalence and Associations of Systemic Inflammation in Heart Failure Across the Spectrum of Ejection Fraction.JACC. Heart failure · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe heart failure with preserved ejection fraction (HFpEF) scores were initially developed to facilitate diagnosis of HFpEF in patients with dyspnea. Whether these diagnostic scores also relate to severity of cardiopulmonary reserve limitations across the broad range of patients with dyspnea, with or without confirmed HFpEF, remains unclear.
objectivesThe purpose of this study was to investigate the association between HFpEF scores and disease severity in patients with dyspnea.
methodsPatients undergoing invasive cardiopulmonary exercise testing for unexplained dyspnea were studied. Cardiac structure, function, and cardiopulmonary reserve were compared based on H
resultsA total of 1,130 subjects were included in this study, of whom 902 had HFpEF and 228 had noncardiac dyspnea. Patients were categorized by HFpEF-ABA score into low (probability <25%, n = 91), intermediate (probability 25%-80%, n = 559), and high HFpEF probabilities (probability >80%, n = 480). Patients with high HFpEF-ABA score exhibited more severe structural and functional abnormalities characteristic of HFpEF, across virtually all morphological and functional indices, as well as hemodynamic and cardiopulmonary indices. Similar findings were observed using the H
conclusionsThe HFpEF scores stratify the extent of cardiac dysfunction, hemodynamic severity, and functional limitation in a broad cohort of individuals with chronic dyspnea, across the overall cohort and within individuals with or without HFpEF. These data indicate that HFpEF probability scores may also be used as markers of disease severity and preclinical HFpEF.
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