Observational studyNeurology2025
History of Pregnancy Complications and the Risk of Ischemic Stroke in Young Women.
Observational study in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Long-term neurological consequences of hypertensive disorders of pregnancy: Implications for postpartum monitoring and intervention.World journal of methodology · 2026Article
- Young stroke: An update on epidemiology, emerging risk factors, and future research directions.International journal of stroke : official journal of the International Stroke Society · 2026Review
Corrections and comments
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Authors and funding
30 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPregnancy complications, such as hypertensive disorders of pregnancy (HDP), small for gestational age (SGA), preterm birth, gestational diabetes, stillbirth, and miscarriage, may increase the risk of ischemic stroke several years later. The aim of this study was to quantify the association between a spectrum of pregnancy complications and (the cause of) ischemic stroke in young women (<50 years).
methodsThis study included 358 women (18-49 years) with first-ever imaging-proven ischemic stroke from the Observational Dutch Young Symptomatic StrokE study and 714 women from the Pregnancy and Infant Development Study, frequency-matched on age at most recent pregnancy and gravidity.
resultsWomen with an ischemic stroke at young age (median maternal age = 28 years [IQR = 24-31]) were more likely to have a history of HDP, SGA, preterm birth, gestational diabetes, stillbirth, and miscarriage, compared with women without ischemic stroke (median maternal age = 29 years [IQR = 26-31]). Specifically, the risk of having an ischemic stroke due to (likely) large artery disease, compared with women with a cryptogenic stroke, was increased for women with a history of HDP, SGA, and preterm birth. DISCUSSION: A history of pregnancy complications may identify women at increased risk of ischemic stroke at young age, in particular atherosclerotic stroke.
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