ArticleAging and disease2025
Exploring the Cerebro-Renovascular Link: Implications of Renal Haemodynamics on Intracranial Arterial Calcification.
Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence hints that the cerebro-renovascular pathway could offer promising approaches to enhancing renal health and reducing the associated risk and burden of intracranial arterial calcification (IAC), a crucial marker for ageing-related intracranial atherosclerosis. This study explored whether renal function and renovascular haemodynamic metrics could predict the severity and load of IAC and elucidate the clinical distinctiveness between intimal and medial IAC. Seventy-seven Chinese participants were enrolled in this cross-sectional study. Kidney functions were evaluated using the estimated glomerular filtration rate (eGFR). Renovascular haemodynamics (on resistance) was assessed using duplex ultrasound to record metrics such as the resistive index (RI) of renal and interlobar arteries. Non-enhanced computed tomography (CT) assessed the count, severity, and load of IAC and classified IAC into intimal and medial. Regression models were fitted for analyses. Among 69 patients with IAC, 29% exhibited predominantly intimal and 71% predominantly medial calcification. Of those with IAC, 26 (37.7%) had an eGFR below 60 ml/min/1.73m², 19 (27.5%) had values between 60-90 ml/min/1.73m², and 24 (34.8%) had scores above 90 ml/min/1.73m². Measures of eGFR <60 ml/min/1.73m² were independently associated with higher renal RI [adjusted OR=3.45 (95%CI: 1.38-8.59, p=.008)]. Patients with predominantly medial IAC had higher renovascular resistance. Higher renal RI independently predicted higher IAC load [adjusted OR=1.88 (95%CI: 1.06-3.35, p=0.032)]. In summary, renovascular haemodynamics significantly determine the load and severity of IAC, particularly in individuals with reduced renal function (eGFR <60 ml/min/1.73m²). The impact of renal impairment is more pronounced on medial IAC than on intimal IAC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.