ArticleScience advances2025
Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A full-range sweat rate sensor with superhydrophobic heterophase shunt for psychology, skin health and body dehydration evaluating.Science advances · 2026Article
- Beyond Detection Limits: Integrated Biosensors for Molecular Diagnostics, Longitudinal Monitoring, and Clinical Translation.Biosensors · 2026Review
- AI-Ready Multimodal Wearable Biosensors Beyond Glucose: Biofluid Sampling, Sensor Fusion, and Clinical Translation.Biosensors · 2026Review
- Smart wearable biosensors: a transformative synergy between diagnosis and treatment of disease.RSC advances · 2026Review
- Applications of Wearable Sweat Biosensors in Sports Activities with Real-World Cases.Bioengineering (Basel, Switzerland) · 2026Review
- Regulating the Nano-Bio Interface: Converging Electrochemical and Photonic Biosensing for Wearable Diagnostics.Nano letters · 2026Review
- Wearable Sensing for Clinical Physiology Monitoring: Emerging Paradigms.Physiology (Bethesda, Md.) · 2026Review
- Modeling and validation of parallel co-flows layer widths in open-capillary trigger valve systems.bioRxiv : the preprint server for biology · 2026Article
- Biomolecular profiling for noninvasive health monitoring.Nature biotechnology · 2026Review
- Nanostructured electrode materials and flexible-substrate engineering for wearable multi-analyte biosensors in diabetes monitoring and personalized care: a comprehensive review.Journal of materials science. Materials in medicine · 2026Review
- Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Real-time nanomolar vitamin monitoring in sweat using an electrochemical skin-attached device.Nature communications · 2026Article
- Multidimensional and Multifunctional Laser-Induced Graphene (LIG) for Point-of-Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- AI-Assisted Molecular Biosensors: Design Strategies for Wearable and Real-Time Monitoring.International journal of molecular sciences · 2026Review
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A Method for Assessing Week-Long Cortisol Output Using a Continuously Worn Sweat Patch.Methods and protocols · 2026Article
- Review
- Multimodal flexible sensor system toward telediagnosis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026Review
- Printed Sensors for Quantifying Electrodermal Activity and Sweat Rate: A Review.Sensors (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Managing stress is essential for mental and physical health, yet current methods rely on subjective self-assessments or indirect physiological measurements, often lacking accuracy. Existing wearable sensors primarily target a single stress hormone, cortisol, using single-point measurements that fail to capture real-time changes and distinguish between acute and chronic stress. To address this, we present Stressomic, a wearable multiplexed microfluidic biosensor for noninvasive monitoring of cortisol, epinephrine, and norepinephrine in sweat. Stressomic integrates iontophoresis-driven sweat extraction with bursting valve-regulated microfluidic channels for continuous sampling and analysis. Gold nanodendrite-decorated laser-engraved graphene electrodes achieve picomolar-level sensitivity, enabling simultaneous detection of multiple stress hormones. Electrochemical assays and human studies demonstrate that Stressomic reliably tracks hormone fluctuations in response to physical, psychological, and pharmacological stressors. Distinct temporal patterns reveal the dynamic interplay between the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. This platform enables continuous, multiplexed stress profiling, offering opportunities for early detection of maladaptive responses, personalized stress management, and deeper insights into stress biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.