Evidence map›Paper›PMID 40768578›Full record

ArticleScience advances2025

A closed-loop bioelectronic patch for intelligent blood pressure management.

Yuyan Zou, Zeguo Chen, Bowen Jin, Linghui Lyu, Yongting Xie, Yuqing Li, Ke Zeng, Siqi Yan, Zhongshi Wu, Wansong Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuyan ZouHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.ORCID 0000-0003-1759-2244
Zeguo ChenDepartment of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410083, China.
Bowen JinHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
Linghui LyuHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
Yongting XieHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
Yuqing LiHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.ORCID 0000-0001-9315-6810
Ke ZengHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
Siqi YanInstitute for Stem Cell and Regenerative Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Zhongshi WuDepartment of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410083, China.
Wansong ChenHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.ORCID 0000-0002-3426-2653
You-Nian LiuHunan Provincial Key Laboratory of Micro and Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.ORCID 0000-0002-7078-5937
Yanli ZhaoSchool of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.ORCID 0000-0002-9231-8360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases remain a leading cause of mortality due to passive and delayed drug interventions. This study introduces an intelligent blood pressure management system (BPMS) for real-time monitoring and adaptive intervention through a closed-loop framework integrating sensors, control circuits, and microneedle electrodes. A hierarchical microneedle architecture, featuring gold nanoparticle (Au NP) electrocatalysts and copper-nitrogen-doped carbon nanoribbon (Cu-NC NB) nanozymes, selectively catalyzes the in situ generation of nitric oxide (NO) for vasodilation. To enhance NO delivery, an electroosmotic flow (EOF) mechanism extends the diffusion range up to 4 millimeters through a porous microneedle (PMN) array, enabling effective vascular penetration. In vivo studies in rabbits and pigs confirm that BPMS dynamically regulates NO release in response to fluctuating blood pressure, achieving real-time hemodynamic control. This work pioneers a closed-loop strategy for continuous blood pressure monitoring and on-demand vasodilation, offering a transformative approach to the intelligent management of cardiovascular diseases.

Indexed as

Blood PressureBlood Pressure DeterminationAnimalsGoldHumansMetal NanoparticlesNitric OxideRabbitsSwineVasodilationGoldNitric Oxide

Identifiers

PMID40768578
PMCPMC12327451

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.