ArticleScience advances2025
A streamlined CRISPR-based test for tuberculosis detection directly from sputum.
Abstract read
In one paragraph
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Multiplexed detection of febrile infections using CARMEN.Nature communications · 2025Trial
- Clinical Evaluation of a Tandem qPCR-CRISPR Assay for Multidrug-Resistant or Rifampicin-Resistant Tuberculosis: A Prospective Diagnostic Accuracy Study.Microorganisms · 2026Article
- Systematic Position Mapping of Split CRISPR-Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cas-regulation-targeting chimera enables selective and tunable control of CRISPR/Cas12a.Nucleic acids research · 2026Article
- Intersegmental transfers drive target search in an RNA-targeting CRISPR system.bioRxiv : the preprint server for biology · 2026Article
- Deep Learning-Assisted Digital Microfluidic Platform for Automated CRISPR/Cas12 Detection ofACS measurement science au · 2026Article
- Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak.Nature communications · 2026Article
- Integrated Optothermal Paperfluidic Platform for Single-Step, Model-Driven CRISPR-Cas12a Diagnostics ofACS omega · 2026Article
- Towards deployable CRISPR-based nucleic acid detection.Progress in biomedical engineering (Bristol, England) · 2026Review
- Development of a multifunctional nucleic acid response platform utilizing the Cas12a and Cas13a integrated targeting system.Nucleic acids research · 2026Article
- From Cell-Free Transcriptomes to Single-Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An Efficient Workflow for Fungal Nucleic Acid Detection in Sputum.Journal of fungi (Basel, Switzerland) · 2026Article
- Recognition, Signal Transduction, and Amplification of Nucleic Acids Under Isothermal Condition.Advanced genetics (Hoboken, N.J.) · 2026Article
- crRNA scaffold remodeling controls CRISPR-Cas12a activity for enhanced performance.Nucleic acids research · 2026Article
- Advancing Tuberculosis Treatment with Next-Generation Drugs and Smart Delivery Systems.Pharmaceutics · 2026Review
- From gaps to progress: five-year global advances in the diagnosis of pediatric tuberculosis.Frontiers in pediatrics · 2026Review
- From mutation detection to treatment decisions: CRISPR-enabled diagnostics for drug-resistant tuberculosis.Frontiers in bioengineering and biotechnology · 2026Review
- Sensitive pathogen DNA detection by a multi-guide RNA Cas12a assay favoring trans- versus cis-cleavage.Nature communications · 2025Article
- A handheld microfluidic manifold for massively multiplexed CRISPR-based nucleic acid detection.bioRxiv : the preprint server for biology · 2025Article
- Simplified Co-extraction of total Nucleic Acids from Respiratory Samples for detection ofmedRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
- Update of
Authors and funding
12 authors.
Alexandra G BellDepartment of Molecular Biology, Princeton University, Princeton NJ 08544, USA.ORCID 0009-0001-2036-0455
Owen R S DunkleyDepartment of Molecular Biology, Princeton University, Princeton NJ 08544, USA.ORCID 0009-0005-6495-3657
Nisha H ModiPublic Health Research Institute, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0009-0006-4243-9742
Yujia HuangDepartment of Molecular Biology, Princeton University, Princeton NJ 08544, USA.ORCID 0009-0001-7316-3930
Soleil TsengDepartment of Molecular Biology, Princeton University, Princeton NJ 08544, USA.ORCID 0009-0007-8080-9692
Robert ReissPublic Health Research Institute, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0002-1131-0907
Naranjargal DaivaaPublic Health Research Institute, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0009-0007-8393-3250
J Lucian DavisDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.ORCID 0000-0002-8629-9992
Deninson Alejandro VargasCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.ORCID 0000-0002-6575-1919
Padmapriya BanadaPublic Health Research Institute, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0002-5217-6142
Yingda L XiePublic Health Research Institute, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0001-5587-4731
Cameron MyhrvoldDepartment of Molecular Biology, Princeton University, Princeton NJ 08544, USA.ORCID 0000-0002-8971-184X
Funding
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4MMethods and Logic in Molecular Biology Training ProgramT32GM148739 · NIGMS · PRINCETON UNIVERSITY · PI Ileana M. Cristea · 2023 to 2026
$3.6MDevelopment of a highly-multiplexed CRISPR-based TB drug susceptibility testR01AI182281 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Cameron Amadeus Myhrvold, Yingda Linda Xie · 2024 to 2026
$2.2MDevelopment of a rapid multiplex CRISPR-based testing pathway for tuberculosis and COVID-19R21AI168808 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BANADA, PADMAPRIYA, MYHRVOLD, CAMERON AMADEUS · 2022 to 2023
$438kMobile Health and Oral Testing to Optimize Tuberculosis Contact Tracing in ColombiaR21AI174129 · NIAID · YALE UNIVERSITY · PI DAVIS, JOHN LUCIAN · 2023 to 2024
$381kNCATS NIH HHS UL1 TR003017NIAID NIH HHS R01 AI182281NIAID NIH HHS R21 AI168808NIAID NIH HHS R21 AI174129NIGMS NIH HHS T32 GM007388NIGMS NIH HHS T32 GM148739
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsMycobacterium tuberculosisSputumTuberculosisHumansNucleic Acid Amplification TechniquesSensitivity and Specificity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.