Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Zhuqing LiDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0003-4709-4588
Yihan PengDepartment of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.ORCID 0000-0002-7589-661X
Huai-Chin ChiangDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0002-7616-3362
Yanjun GaoDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0009-0000-0527-3479
Chen ChuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0001-8084-0867
Yi ZhangDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0001-6881-384X
Muhammad Jameel MughalDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0002-3982-5136
Chengyu LiuThe Transgenic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5136-9225
Rong LiDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Huadong PeiDepartment of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.ORCID 0000-0002-1706-1745
Wenge ZhuDepartment of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0001-9113-5020
Funding
T Cell-Specific BRCA1 Function in Antitumor Immunity and ImmunotherapyR01CA282303 · NCI · GEORGE WASHINGTON UNIVERSITY · PI YANFEN HU, Rong Li · 2023 to 2026
$2.4M
The role of And-1 in nucleotide excision repairR01CA258357 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Wenge Zhu · 2022 to 2026
$2.2M
Targeting Fanconi Anemia pathway to overcome platinum drug resistance in ovarian cancerR01CA247684 · NCI · GEORGE WASHINGTON UNIVERSITY · PI ZHU, WENGE · 2021 to 2025
$2.1M
The role of histidine phosphorylation in the DNA alkylation damage responseR01CA270153 · NCI · GEORGETOWN UNIVERSITY · PI Huadong Pei · 2023 to 2026
$1.5M
The role of And-1 in R-loop and endocrine resistance in breast cancerR01CA288337 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Wenge Zhu · 2025 to 2026
R-loops are three-stranded DNA/RNA hybrids that are essential for various cellular pathways. However, when dysregulated, they lead to genomic instability and numerous human diseases. R-loops are tightly regulated, with RNase H1 acting as a key enzyme responsible for resolving DNA/RNA hybrids. Here, we identify the DNA-binding protein AND-1 as an essential factor in R-loop regulation through directly binding to R-loop structures, where it enhances the recruitment of RNase H1 and stimulates its endonuclease activity. We also provide in vivo evidence that R-loop accumulation occurs in the mammary gland tissue of AND-1-deficient mice. Furthermore, we demonstrate that inhibition of AND-1 decreases
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance. · full record | OpenQuestion