Trial reportHuman vaccines & immunotherapeutics2025
CARD (Comfort Ask Relax Distract) and community pharmacy vaccinations: Evaluation of effectiveness outcomes from a cluster randomized trial.
Trial report in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Reducing distress during vaccine injections: 2026 clinical practice guideline update.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Guideline
- A Systematic Review and Meta-Analysis of the Effectiveness of Procedural Interventions for Reducing Distress During Vaccine Injections.The Clinical journal of pain · 2026Pooled it
- A Systematic Review and Meta-Analysis of the Effectiveness of Process Interventions for Reducing Distress During Vaccine Injections.The Clinical journal of pain · 2026Pooled it
- A Systematic Review and Meta-Analysis of Psychological Interventions for Reducing Distress During Vaccine Injections.The Clinical journal of pain · 2026Pooled it
- From Evidence to Practice: Implementing the 2026 Canadian Clinical Practice Guideline Update on Vaccination-Related Distress in the Dutch National Immunization Program.The Clinical journal of pain · 2026Article
- Commentary: Improving the vaccination experience for children and adults.Human vaccines & immunotherapeutics · 2025Article
- Playing CARD (Comfort Ask Relax Distract): Upping our game on the quality of vaccine delivery.Human vaccines & immunotherapeutics · 2025Article
- Development and refinement of an online CARD (Comfort Ask Relax Distract) course for organizations and providers delivering vaccinations and other needle procedures.Human vaccines & immunotherapeutics · 2025Article
- Effect of CARD (Comfort-Ask-Relax-Distract) on acceptance of school-based vaccinations: A controlled before and after study.Human vaccines & immunotherapeutics · 2025Article
- Using the CARD system for university-based pop-up vaccination clinics: A two-stage hybrid effectiveness-implementation study.Human vaccines & immunotherapeutics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While community pharmacies are an efficient setting for vaccinating large numbers of individuals, they can be stressful for vaccine recipients and providers, creating challenges for vaccine delivery. The CARD system (Comfort Ask Relax Distract) is an evidence-based protocol for vaccination delivery designed to improve the vaccination experience. A hybrid effectiveness-implementation cluster randomized trial was conducted between November 2023 and January 2024 whereby 25 pharmacies in Ontario (Canada) were randomly allocated to CARD training and resources (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.