Evidence map›Paper›PMID 40768460›Full record

SynthesisIEEE journal of biomedical and health informatics2026

Transformer-Based Deep Learning Approaches for Speech-Based Dementia Detection: A Systematic Review.

Pooyan Mobtahej, Sam T Gouron, Rojan Javaheri, Dennis N Le, Annelisse El-Khoury, Thiri Htet Naing, S Ahmad Sajjadi

Abstract readSystematic Review
In one paragraph

Synthesis in IEEE journal of biomedical and health informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pooyan Mobtahej
Sam T Gouron
Rojan Javaheri
Dennis N Le
Annelisse El-Khoury
Thiri Htet Naing
S Ahmad Sajjadi

Funding

The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Diagnosis and Risk factors of hippocampal sclerosis of aging and limbic predominant age related TDP-43 encephalopathy; common Alzheimer’s mimicsR01AG062706 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Seyed Ahmad Sajjadi · 2019 to 2026
$9.2M
Training in Translational ADRD Neuroscience (TITAN)T32AG073088 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2021 to 2026
$2.2M
NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG062706NIA NIH HHS T32 AG073088
6 · The paper itself

Abstract

As the population of older adults continues growing, so will the need for cost-effective approaches to early dementia detection. Deep learning approaches using patient speech samples show promising results. This systematic review examines studies utilizing speech-based deep learning for dementia diagnosis with the objective of identifying best practices for future data-driven dementia research. Studies researching speech-based deep learning for dementia were obtained from PubMed, Wiley Library, Science Direct, IEEE, Web of Science, Google Scholar, and arXiv. 80 studies were reviewed. Studies were analyzed in terms of model architecture and performance, speech features employed, and databases used. We observed that transformer-based approaches were most frequent, achieving an average accuracy of 85.71%, and that linguistic features outperform acoustic features. Our review identified several limitations, including a lack of dataset diversity, inconsistent classification of dementia severity levels across studies, and variability in how sample sizes and model performance metrics (e.g., accuracy, sensitivity, specificity) are reported. These inconsistencies hinder direct comparisons between studies and limit the reproducibility of findings. Still, our findings suggest that incorporation of transformers into current speech-based deep learning models can further improve detection of cognitive impairment. Consideration of our observations in future data-driven dementia research will lead to advancements in the development of diagnostic decision support systems for clinical practice.

Indexed as

Deep LearningDementiaDiagnosis, Computer-AssistedSpeechHumans

Identifiers

PMID40768460
PMCPMC13008316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.