Evidence map›Paper›PMID 40768360›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Structural insights into proteolysis-dependent and -independent suppression of the master regulator DELLA by the gibberellin receptor.

Pawan Dahal, Yan Wang, Jianhong Hu, Jeongmoo Park, Karly Forker, Zhong-Lin Zhang, Kedar Sharma, Mario J Borgnia, Tai-Ping Sun, Pei Zhou

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Structure-guided optimization of SLY1 expression and purification in Escherichia coli.Protein science : a publication of the Protein Society · 2026
    Article
  11. Article
  12. Article
  13. The molecular structure of the master growth regulator in plants emerges into the spotlight.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Pawan Dahal *Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710.
Yan Wang *Department of Biology, Duke University, Durham, NC 27708.ORCID 0000-0003-3262-9930
Jianhong HuDepartment of Biology, Duke University, Durham, NC 27708.
Jeongmoo ParkDepartment of Biology, Duke University, Durham, NC 27708.
Karly ForkerDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.
Zhong-Lin ZhangDepartment of Biology, Duke University, Durham, NC 27708.
Kedar SharmaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Mario J BorgniaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.ORCID 0000-0001-9159-1413
Tai-Ping SunDepartment of Biology, Duke University, Durham, NC 27708.
Pei ZhouDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.ORCID 0000-0002-7823-3416

Funding

NIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0M
Structure and Function Analyses of DELLA Interacting Proteins in ArabidopsisR01GM100051 · NIGMS · DUKE UNIVERSITY · PI SUN, TAI-PING · 2012 to 2021
$2.4M
Structural and Functional Analysis of Nucleocytoplasmic Protein O-Glycosyltransferases in PlantsR01GM150029 · NIGMS · DUKE UNIVERSITY · PI Tai-Ping Sun, Pei Zhou · 2023 to 2026
$1.9M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM100051HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM150029Intramural NIH HHS ZIC ES103326NIGMS NIH HHS R01 GM100051NIGMS NIH HHS R01 GM150029NSF | BIO | Division of Molecular and Cellular Biosciences (MCB) MCB-2416564
6 · The paper itself

Abstract

The perception of the phytohormone gibberellin (GA) by its nuclear receptor GIBBERELLIN INSENSITIVE DWARF1 (GID1) triggers polyubiquitination and proteasomal degradation of master growth regulators-DELLA proteins-mediated by the SCF

Indexed as

ArabidopsisArabidopsis ProteinsGibberellinsReceptors, Cell SurfaceCryoelectron MicroscopyPlant Growth RegulatorsProtein BindingProtein DomainsProteolysisArabidopsis ProteinsGAI protein, ArabidopsisGibberellinsGID1a protein, ArabidopsisPlant Growth RegulatorsReceptors, Cell SurfaceDELLAgibberellin receptorgibberellin signaling

Identifiers

PMID40768360
PMCPMC12358861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.