Evidence map›Paper›PMID 40768336›Full record

ArticleCell reports2025

The neurexin gene family regulates olfactory glomerular formation.

Sung Jin Park, Namgyu Lee, I-Hao Wang, Hao-Ching Jiang, Thuyvan Luu, Takeshi Uemura, Kensuke Futai, Dohoon Kim, Evan Macosko, Paul Greer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sung Jin ParkProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea; Department of Biomedical Science & Engineering, Dankook University, Cheonan, South Korea. Electronic address: parksj1126@skku.edu.
Namgyu LeeDepartment of Biomedical Science & Engineering, Dankook University, Cheonan, South Korea.
I-Hao WangProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Hao-Ching JiangProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Thuyvan LuuProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Takeshi UemuraDivision of Gene Research, Research Center for Advanced Science, Shinshu University, Nagano, Japan; Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Nagano, Japan.
Kensuke FutaiDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Dohoon KimDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Evan MacoskoBroad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Paul GreerProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: paul.greer@umassmed.edu.

Funding

University of Massachusetts Center for Clinical and Translational ScienceKL2TR001455 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2015 to 2024
$5.0M
Molecular Mechanisms Underlying the sex-Depended Maturation of Modulatory Systems.R01MH130582 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KENSUKE FUTAI · 2022 to 2026
$2.9M
Elucidating the Role of a Novel Family of Chemoreceptor in Alzheimer's DiseaseDP2AG067490 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GREER, PAUL LIEBERMAN · 2019 to 2019
$2.5M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Selenoprotein-independent biological roles for selenium in selenium deficiency and excessR01GM148832 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dohoon Kim · 2023 to 2026
$1.4M
NCATS NIH HHS KL2 TR001455NIAID NIH HHS T32 AI095213NIA NIH HHS DP2 AG067490NIGMS NIH HHS R01 GM148832NIMH NIH HHS R01 MH130582
6 · The paper itself

Abstract

Precise connectivity between specific neurons is essential for the formation of the complex neural circuitry necessary for executing intricate motor behaviors and higher cognitive functions. While trans interactions between synaptic surface proteins have emerged as crucial elements in orchestrating the assembly of neural circuits, the proteins involved in neuronal wiring remain largely unknown. Here, we uncover that the neurexin family of genes enables olfactory sensory neuron (OSN) axons to form appropriate connections with their mitral/tufted (M/T) cell synaptic partners within the olfactory system. Neurexins, which are differentially expressed within distinct populations of OSNs, synergistically cooperate to regulate axonal sorting to designated glomeruli. This process is facilitated through the interactions of neurexins with their postsynaptic partners, which have distinct expression patterns in M/T cells. Our findings suggest a mechanism underpinning the precise assembly of olfactory neural circuits, driven by the trans interaction between neurexins and their ligands.

Indexed as

Cell Adhesion Molecules, NeuronalMultigene FamilyOlfactory BulbOlfactory Receptor NeuronsAnimalsAxonsMiceMice, Inbred C57BLSynapsesCell Adhesion Molecules, Neuronalaxon guidanceCP: Neuroscienceneural connectionneurexinneuroliginolfactorywiring

Identifiers

PMID40768336
PMCPMC12688019

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.