ArticleCell reports2025
CD138 and APRIL regulate plasma cell survival, competition, and retention in the bone marrow niche.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Spatial transcriptomics identifies a suppressive, T-cell-excluded tumor microenvironment in extramedullary myeloma.Blood advances · 2026Article
- Ex vivo bone marrow subniches influence the fate of human antibody-secreting cells.Science advances · 2026Article
- Review
- Protocol for selective in vivo labeling of bone marrow plasma cells by intrafemoral antibody injection in mice.STAR protocols · 2026Article
- Engineering bone marrow in a dish-a bloody business: preclinical opportunities, translational use cases, and a call for consensus.Journal of thrombosis and haemostasis : JTH · 2026Review
- Heparan Sulfate Proteoglycans in Immunity.Proteoglycan research · 2026Article
- Not all plasma cells are made equal: well-hidden layers of heterogeneity.Frontiers in immunology · 2026Review
- Why are long-lived plasma cells long-lived?Frontiers in immunology · 2026Review
- Radiation resistance is a property of long-lived plasma cells but not their precursors.Immunotherapy advances · 2026Article
- The evolution of antibody-secreting cell biological exploration: one mouse model at a time.Frontiers in immunology · 2026Review
- Resolving the renal microenvironment: a 5-plex immunofluorescence workflow to quantify B-lineage cells in FFPE lupus nephritis biopsies.Frontiers in immunology · 2026Article
- Article
- Developmental trajectory of long-lived plasma cells.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Durable serological protection is maintained through the persistence of antigen-specific plasma cells (PCs), but key factors regulating the survival of nascent PCs remain unclear. Previously, we reported that bone marrow (BM) PCs partially organize into clusters that are enriched for long-lived PCs, suggesting that clusters are survival niches. Here, we report that acute blockade of a proliferation-inducing ligand (APRIL) and B cell activating factor (BAFF) using transmembrane activator and CAML interactor (TACI)-Fc rapidly disrupts clusters and mobilizes BM PCs. CD138, a surface co-receptor that is abundant on PCs and binds APRIL but not BAFF, regulates PC retention in the BM and adhesion and motility on fibronectin. Cell-intrinsic CD138 levels control competition for survival between nascent CD138
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.