ReviewJournal of the American Society of Nephrology : JASN2025
Noninvasive Diagnosis of Kidney Allograft Rejection.
Review in Journal of the American Society of Nephrology : JASN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Integration of intragraft transcriptomics and urinary cytokines identifies CXCL10 and FasL signature in subclinical acute rejection.Scientific reports · 2026Article
- Article
- Lipocalin-2 modulates recipients alloimmune responses to the murine kidney transplants.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Despite regular conventional monitoring of kidney transplant recipients, allograft rejection remains a barrier for the long-term success of kidney transplantation and is one of the leading causes of graft failure. Kidney transplant rejection and graft failure are reported as the most feared outcomes by patients. Timely diagnosis of rejection and early treatment enables interventions that may attenuate alloimmune processes before irreversible graft injury has occurred. The evolving landscape of noninvasive diagnostic tools presents promising opportunities for early detection of kidney allograft rejection. These tools, alone or combined, may promptly signal the need for a biopsy, reduce the need for surveillance biopsies, or even potentially inform treatment monitoring. Therefore, they are of utmost importance, and their use should be informed by evidence, guiding both patients and their clinical teams. This review will cover noninvasive tests used for the diagnosis of kidney allograft rejection available or soon to be available in the clinical setting and describe their diagnostic context, strengths, and limitations, while proposing an ideal clinical framework for their use.
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Registered trials
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