Evidence map›Paper›PMID 40768266›Full record

ArticleEpigenomics2025

DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients.

Shuwei Liu, Dongjing Liu, Catherine M Bender, Kirk I Erickson, Susan M Sereika, John R Shaffer, Daniel E Weeks, Yvette P Conley

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02793921 (Influence of Exercise on Neurocognitive Function in Breast Cancer), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02793921 nacompletednot on this map

Influence of Exercise on Neurocognitive Function in Breast Cancer

TypeinterventionalSponsorUniversity of PittsburghRan2016 to 2023Enrolled153ConditionsBreast CancerArmsModerate-Intensity Aerobic Exercise Intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Biological research for nursing · 2026
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shuwei LiuDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4089-8359
Dongjing LiuDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9520-7789
Catherine M BenderSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1205-9950
Kirk I EricksonDepartment of Psychology, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8736-981X
Susan M SereikaSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7840-1352
John R ShafferDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-1897-1131
Daniel E WeeksDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9410-7228
Yvette P ConleyDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1784-6067

Funding

Influence of Exercise on Neurocognitive Function in Breast CancerR01CA196762 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M., ERICKSON, KIRK I · 2016 to 2020
$3.0M
Epigenomics of Neurocognitive Function in Breast CancerR01CA221882 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M., CONLEY, YVETTE P · 2018 to 2022
$2.2M
NCI NIH HHS R01 CA196762NCI NIH HHS R01 CA221882
6 · The paper itself

Abstract

backgroundApproximately one-third of breast cancer (BC) patients show poorer cognitive function (CF). Using DNA methylation (DNAm) data, here we aimed to identify genes and biological pathways associated with CF in postmenopausal women with early-stage hormone receptor-positive (HR+) BC.

methodsEpigenome-wide association studies (EWAS) and differentially methylated region analyses were performed for each CF phenotype (seven objective domains and one subjective phenotype) using DNAm data from whole blood samples (

resultsWhen adjusting for age, verbal IQ scores, and global DNAm signature, cg10331779 near

conclusionsIn our EWAS of 8 CF phenotypes, we found two epigenome-wide significant signals, one for processing speed and the other for subjective CF. We also found three differentially methylated regions associated with processing speed and two associated with mental flexibility. CLINICAL

trial registrationwww.clinicaltrials.gov identifier is NCT02793921.

Indexed as

Breast NeoplasmsCognitionDNA MethylationAgedEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansMiddle AgedRandomized Controlled Trials as TopicReceptors, EstrogenReceptors, ProgesteroneReceptors, EstrogenReceptors, ProgesteroneBreast cancercognitive functionDNA methylationepigenome-wide association studyestrogen

Identifiers

PMID40768266
PMCPMC12369613

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.