Evidence map›Paper›PMID 40768115›Full record

ArticleMolecular neurobiology2025

Komagataella pastoris KM71H Attenuates Cognitive Deficits and Depressive-Like Behavior by the TLR4/NF-κB Signaling Pathway in an Aβ

Paloma T Birmann, Giuliana Petiz Zugno, Airton Sinott, Rafael R Rodrigues, Fabricio R Conceição, Fernanda Severo Sabedra Sousa, Tiago Collares, Fabiana K Seixas, Lucielli Savegnago

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paloma T BirmannNeurobiotechnology Research Group, Graduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Giuliana Petiz ZugnoNeurobiotechnology Research Group, Graduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Airton SinottNeurobiotechnology Research Group, Graduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Rafael R RodriguesApplied Immunology Laboratory, Graduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Fabricio R ConceiçãoApplied Immunology Laboratory, Graduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Fernanda Severo Sabedra SousaMolecular and Cellular Oncology Research Group and Functional Genomics Laboratory, Graduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Tiago CollaresMolecular and Cellular Oncology Research Group and Functional Genomics Laboratory, Graduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Fabiana K SeixasMolecular and Cellular Oncology Research Group and Functional Genomics Laboratory, Graduate Program in Biotechnology, Technological Development Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Lucielli SavegnagoNeurobiotechnology Research Group, Graduate Program in Biotechnology, Technologic Development Center, Federal University of Pelotas, Pelotas, RS, Brazil. luciellisavegnago@yahoo.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Komagataella pastoris is a promising probiotic for modulating the microbiota-gut-brain axis, and growing evidence has demonstrated the relevance of this axis in the pathophysiology of neurological and psychiatric disorders, such as Alzheimer's disease and major depressive disorder. This study investigated the ameliorated cognitive impairment and antidepressive-like effect of K. pastoris treatment on an AD-like mouse model induced by amyloid β

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionDepressionNF-kappa BPeptide FragmentsSignal TransductionToll-Like Receptor 4AnimalsBehavior, AnimalDisease Models, AnimalHippocampusMaleMiceAmyloid beta-Peptidesamyloid beta-protein (1-40)NF-kappa BPeptide FragmentsToll-Like Receptor 4CognitiveDepressionMicrobiota-gut-brain axisProbioticYeast

Identifiers

PMID40768115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.