ArticleMikrochimica acta2025
Development of an electrochemical sensor using molecularly imprinted polymers for the specific determination of the antiretroviral drug ritonavir.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
An innovative sensor technology is introduced that employs molecularly imprinted polymers (MIPs) for the electrochemical detection of ritonavir (RTV), a protease inhibitor utilized in HIV therapy. RTV is frequently used in combination with other drugs since it is also a significant inhibitor of the P450 3A4 isoenzyme. Therefore, accurate detection of RTV in complex mixtures and intricate biological matrices is necessary to evaluate the therapeutic efficacy of RTV. A polymeric layer was formed on the surface of the glassy carbon electrode (GCE) using RTV as the template molecule, methacrylic acid (MAA) as the functional monomer, and aniline in a phosphate buffer at pH 7. The morphological and electrochemical characteristics of the RTV/ANI-co-MAA@MIP-GCE sensor were assessed through scanning electron microscopy, Fourier transform infrared spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. The sensor exhibited a linear detection range for RTV utilizing a redox probe (5.0 mM [Fe(CN)
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