Evidence map›Paper›PMID 40768069›Full record

Observational studyIntensive care medicine2025

Norepinephrine use at extubation in critically ill patients with obesity: a cohort study with multicenter validation.

Audrey De Jong, Mathieu Capdevila, Yassir Aarab, Francesca Rabboni, Alina Kozoriz, Guillaume Heupel, Joris Pensier, Ines Lakbar, Clément Monet, Gérald Chanques and 1 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04014920 (Non-invasive Ventilation Following Extubation), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04014920 nacompletednot on this map

Non-invasive Ventilation Following Extubation (Prophylactic) to Prevent Extubation Failure in Critically Obese Patients: a Prospective, Randomized, Multicenter Study

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2019 to 2021Enrolled1,000ConditionsObesity, Ventilation, Intensive Care UnitArmsOxygen group, NIV Group
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Audrey De JongIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France. a-de_jong@chu-montpellier.fr.ORCID 0000-0002-3413-2752
Mathieu CapdevilaIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Yassir AarabIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Francesca RabboniIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Alina KozorizIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Guillaume HeupelIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Joris PensierIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Ines LakbarIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Clément MonetIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Gérald ChanquesIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.
Samir JaberIntensive Care Unit, Anesthesia and Critical Care Department, Saint Eloi Teaching Hospital, University Montpellier 1, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to assess whether norepinephrine at the time of extubation increases reintubation rates in critically ill patients with obesity.

methodsThe initial step was to analyze data that had been collected prospectively, using a retrospective approach-defined as the main cohort. Then, we validated our findings using data from a multicenter randomized-controlled trial (validation cohort). The primary objective was to compare reintubation within 7 days, between patients with norepinephrine and without norepinephrine at the time of extubation. The secondary objective was to assess norepinephrine doses at extubation, normalized to body weight.

resultsAmong the 3186 patients included in the main cohort, 837 had obesity. Among them, 213 (25%) were extubated with norepinephrine, with a median norepinephrine dose at extubation of 0.6 mg/h of absolute value which corresponds to 0.097 (0.04-0.17) µg/kg/min of real body weight. No significant difference in reintubation rates was observed between patients extubated with norepinephrine (16%) and those without (17%, p = 0.85). Among the 656 patients with obesity in the validation cohort, we observed similar results, with a reintubation rate of 18% in those extubated with norepinephrine and 15% in those without (p = 0.45). Similar results were observed in the 2349 patients without obesity.

interpretationIn critically ill patients with obesity, the use of norepinephrine at the time of extubation did not significantly increase the reintubation rates. CLINICAL

trial registrationNCT04014920 for the validation cohort.

Indexed as

Airway ExtubationCritical IllnessNorepinephrineObesityAgedCohort StudiesFemaleHumansIntensive Care UnitsMaleMiddle AgedRandomized Controlled Trials as TopicRetrospective StudiesNorepinephrineCritical careExtubation failureICUIntensive care unitNorepinephrineObesityVasopressorsWeaning

Identifiers

PMID40768069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.