Evidence map›Paper›PMID 40768027›Full record

SynthesisReproductive sciences (Thousand Oaks, Calif.)2025

The Functional Role of Cumulus Cells and Their Influence on Oocyte Quality: A Systematic Review.

Matthew C H Rohn, Jocelyn M Simeone, Steven Doctorman, Peixi Ge, Ana Hernandez, Samarjit Das, Marcus Spann, Mark Dow, James Segars, Bhuchitra Singh

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew C H RohnDepartment of Obstetrics and Gynecology, George Washington University Hospital, Washington, DC, USA.
Jocelyn M SimeoneUniversity of Georgia, Athens, GA, USA.
Steven DoctormanJohns Hopkins University, Baltimore, MD, USA.
Peixi GeJohns Hopkins University, Baltimore, MD, USA.
Ana HernandezJohns Hopkins University, Baltimore, MD, USA.
Samarjit DasDepartment of Pathology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Marcus SpannInformationist Services, Welch Medical Library, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mark DowDivision of Reproductive Endocrinology and Infertility, Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
James SegarsDivision of Reproductive Sciences & Women's Health Research, Department of Gynecology & Obstetrics, Johns Hopkins School of Medicine, 720 Rutland Avenue Ross Research Building, Room 624, Baltimore, MD, 21205, USA.
Bhuchitra SinghDivision of Reproductive Sciences & Women's Health Research, Department of Gynecology & Obstetrics, Johns Hopkins School of Medicine, 720 Rutland Avenue Ross Research Building, Room 624, Baltimore, MD, 21205, USA. bsingh10@jhmi.edu.ORCID 0000-0002-2113-4345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A systematic review was conducted pertaining to the biologic processes of cumulus cells and measures of oocyte quality. The initial search yielded 18,549 articles, and after screening, 65 studies were included in this review. Extracted data were synthesized descriptively. Articles were categorized based on the biologic feature of cumulus cells addressed: genetic expression, biochemical activity, and morphologic characteristics. Manuscripts addressing cumulus cell function in association with gynecologic conditions and their impact on oocyte quality were also reviewed. Findings from six studies showed an association between increased expression of pathways related to extracellular matrix development (HAS2, VCAN) and improved oocyte quality. Six manuscripts reported improved oocyte quality related to genes involved in cumulus cell expansion (GREM1, PTGS2) and 6 articles noted patterns in expression of regulators of apoptotic pathways (BCL2, BIRC5, MDM2, PGAM5). Twelve studies examined biochemical features of cumulus cells, including cumulus mitochondrial membrane resistance, respirometric index, and acetyl-CoA levels, which have been associated with oocyte development. Morphologic assessment of cumulus cells was evaluated by 5 studies, demonstrating a relationship between mitochondrial dimensions, telomere length, and cumulus density/dispersion with oocyte quality. Twenty-two articles assessed cumulus cell function and its relationship with oocyte quality in diseases such as polycystic ovarian syndrome (PCOS) and endometriosis conditions, and increased maternal age (with or without decreased ovarian reserve). This comprehensive systematic review has integrated findings from studies investigating the relationship between cumulus cells and oocyte quality, identifying patterns in gene expression, biochemical features and morphologic assessments that may offer meaningful insight into this relationship.

Indexed as

Cumulus CellsOocytesAnimalsFemaleHumansBiologic processCumulus cellsGeneticMorphologyOocyte quality

Identifiers

PMID40768027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.