Evidence map›Paper›PMID 40767978›Full record

ArticleOral and maxillofacial surgery2025

Variation of mandibular radiomorphometric indices in metastatic bone cancer patients undergoing antiresorptive treatment: a prospective study.

Paolo Boffano, Elena Canciani, Giovanni Galetta, Francesca Boccafoschi, Matteo Brucoli

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Article in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Paolo BoffanoDepartment of Health Sciences, University of Eastern Piedmont, Novara, Italy. paolo.boffano@gmail.com.
Elena CancianiDepartment of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Giovanni GalettaDivision of Maxillofacial Surgery, AOU Maggiore della Carità di Novara, Novara, Italy.
Francesca BoccafoschiDepartment of Health Sciences, University of Eastern Piedmont, Novara, Italy.
Matteo BrucoliDepartment of Health Sciences, University of Eastern Piedmont, Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to identify and evaluate the changes of oral health and panoramic radiograph indexes in cancer patients that have been administered antiresorptive drugs. MATERIALS AND

methodsSubjects who had a diagnosis of cancer with bone metastasis that were about to start antiresorptive therapy with denosumab or zoledronic acid were included. A preliminary dental clinical assessment, together with a panoramic radiograph, was performed at T0 to prevent the onset of Medication related osteonecrosis of the jaw (MRONJ) and T1 (1 year follow up). In order to calculate at both T0 and T1 the mandibular cortical width (MCW), the panoramic mandibular index (PMI), and the mandibular cortical index (MCI), panoramic radiographs were analyzed by a single operator.

resultsThirty-three subjects with a mean age of 59.9 years were included in the study. A significant reduction in the PMI value from T0 to T1 (p = 0.00236) and a significant variation from T0 to T1 for MCI (p < 0.05) were observed.

conclusionsRadiomorphometric indices could represent a promising field of research that can take advantage from the easy detectability in dental panoramic radiographs. Further research is needed to explore the possible role of PMI and MCI in bone cancer patients.

Indexed as

Bone Density Conservation AgentsBone NeoplasmsDenosumabMandibleRadiography, PanoramicAdultAgedBisphosphonate-Associated Osteonecrosis of the JawFemaleHumansMaleMiddle AgedProspective StudiesZoledronic AcidBone Density Conservation AgentsDenosumabZoledronic AcidAntiresorptive drugsBone metastasisDenosumabMandibular cortexRadiomorphometric indices

Identifiers

PMID40767978

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